Bioenxeñería e Cronobioloxía

Artigos Científicos

• Geng Y-J, Madonna R, Hermida RC, Smolensky MH. Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions. Curr Res Pharmacol Drug Discov. 2021;2:100025. DOI: 10.1016/j.crphar.2021.100025. https://doi.org/10.1016/j.crphar.2021.100025 +DOI
• Haghayegh S, Smolensky MH, Khoshnevis S, Hermida RC, Castriotta RJ, Diller KR. The Circadian Rhythm of Thermoregulation Modulates both the Sleep/Wake Cycle and 24 h Pattern of Arterial Blood Pressure. Compr Physiol. 2021;11(4):2645–58. PMID: 34636410. DOI: 10.1002/cphy.c210008. http://www.ncbi.nlm.nih.gov/pubmed/34636410 +Pubmed +DOI
• Hermida RC, Ayala DE, Mojón A, Smolensky MH, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR. Cardiovascular disease risk stratification by the Framigham score is markedly improved by ambulatory compared with office blood pressure. Rev Esp Cardiol (Engl Ed). 2021 Nov;74(11):953–61. PMID: 32950423. DOI: 10.1016/j.rec.2020.08.004. http://www.ncbi.nlm.nih.gov/pubmed/32950423 +Pubmed +DOI
• Hermida RC, Hermida-Ayala RG, Mojón A, Smolensky MH, Fernández JR. Systematic review and quality evaluation of published human ingestion-time trials of blood pressure-lowering medications and their combinations. Chronobiol Int. 2021;38(10):1460–76. PMID: 34107831. DOI: 10.1080/07420528.2021.1931280. http://www.ncbi.nlm.nih.gov/pubmed/34107831 +Pubmed +DOI
• Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Fernández JR. Ingestion-time differences in the pharmacodynamics of hypertension medications: Systematic review of human chronopharmacology trials. Adv Drug Deliv Rev. 2021;170:200–13. PMID: 33486007. DOI: 10.1016/j.addr.2021.01.013. http://www.ncbi.nlm.nih.gov/pubmed/33486007 +Pubmed +DOI
• Hermida RC, Mojón A, Fernández JR, Hermida-Ayala RG, Crespo JJ, Ríos MT, Domínguez-Sardiña M, Otero A, Smolensky MH. Elevated asleep blood pressure and non-dipper 24h patterning best predict risk for heart failure that can be averted by bedtime hypertension chronotherapy: A review of the published literature. Chronobiol Int. 2021 Jun;1–20. PMID: 34190016. DOI: 10.1080/07420528.2021.1939367. http://www.ncbi.nlm.nih.gov/pubmed/34190016 +Pubmed +DOI
• Hermida RC, Mojón A, Hermida-Ayala RG, Smolensky MH, Fernández JR. Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: Systematic review and meta-analysis of published human trials. Sleep Med Rev. 2021;59:101454. PMID: 33571840. DOI: 10.1016/j.smrv.2021.101454. http://www.ncbi.nlm.nih.gov/pubmed/33571840 +Pubmed +DOI
• Hermida RC, Mojón A, Smolensky MH, Fernández JR. Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension-Pro Side of the Argument. Hypertens (Dallas, Tex 1979). 2021 Sep;78(3):879–93. PMID: 34379438. DOI: 10.1161/HYPERTENSIONAHA.120.16500. http://www.ncbi.nlm.nih.gov/pubmed/34379438 +Pubmed +DOI
• Hermida RC, Smolensky MH, Balan H, Castriotta RJ, Crespo JJ, Dagan Y, El-Toukhy S, Fernández JR, FitzGerald GA, Fujimura A, Geng Y-J, Hermida-Ayala RG, Machado AP, Menna-Barreto L, Mojón A, Otero A, Rudic RD, Schernhammer E, Skarke C, Steen TY, Young ME, Zhao X. Guidelines for the design and conduct of human clinical trials on ingestion-time differences – chronopharmacology and chronotherapy – of hypertension medications. Chronobiol Int. 2021;38(1):1–26. PMID: 33342316. DOI: 10.1080/07420528.2020.1850468. http://www.ncbi.nlm.nih.gov/pubmed/33342316 +Pubmed +DOI
• Smolensky MH, Hermida RC, Geng Y-J. Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes. Curr Opin Pharmacol. 2021;57:41–8. PMID: 33279870. DOI: 10.1016/j.coph.2020.10.014. http://www.ncbi.nlm.nih.gov/pubmed/33279870 +Pubmed +DOI
• Smolensky MH, Hermida RC. Commentary on Bowles and Shea: Further perspectives and clinical implications of ingestion-time differences in the efficacy of blood pressure-lowering medications. Sleep Med Rev. 2021;59:101540. PMID: 34425377. DOI: 10.1016/j.smrv.2021.101540. http://www.ncbi.nlm.nih.gov/pubmed/34425377 +Pubmed +DOI

Guías de Práctica

• Crespo JJ, Domínguez-Sardiña M, Ríos MT, Otero-González A, Sineiro E, Callejas-Cabanillas PA, Pousa L, Salgado-Conde JL, Durán-Santos C, Sánchez-Castro JJ, Castiñeira Pérez C, Moya-Álvarez A, Mojón A, Fernández JR, Hermida RC. Fisterra Guías Clínicas: Monitorización ambulatoria de la presión arterial (MAPA). 2021. https://www.fisterra.com/guias-clinicas/monitorizacion-ambulatoria-presion-arterial-mapa/ Enlace

Artigos Científicos

• Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Mojón A, Fernández JR, Hermida RC. Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials. Chronobiol Int. 2020 Jul;37(5):771–80. PMID: 32684071. DOI: 10.1080/07420528.2020.1781351. http://www.ncbi.nlm.nih.gov/pubmed/32684071 +Pubmed +DOI
• Fernández JR, Mojón A, Hermida RC. Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. 2020;37(5):739–50. PMID: 32684004. DOI: 10.1080/07420528.2020.1771355. http://www.ncbi.nlm.nih.gov/pubmed/32684004 +Pubmed +DOI
• Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE, Hygia Project Investigators. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020 Oct;41(48):4565–76. PMID: 31641769. DOI: 10.1093/eurheartj/ehz754. http://www.ncbi.nlm.nih.gov/pubmed/31641769 +Pubmed +DOI
• Hermida RC, Crespo JJ, Domínguez-Sardiña M. Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies. Eur Heart J. 2020 Apr;41(16):1602–3. PMID: 32298422. DOI: 10.1093/eurheartj/ehaa214. http://www.ncbi.nlm.nih.gov/pubmed/32298422 +Pubmed +DOI
• Hermida RC, Fernández JR, Mojón A, Hygia Project Investigators. Chronotherapy of hypertension, asleep ambulatory blood pressure, and glaucoma. Eur Heart J. 2020;41(16):1605. PMID: 32304207. DOI: 10.1093/eurheartj/ehaa215. http://www.ncbi.nlm.nih.gov/pubmed/32304207 +Pubmed +DOI
• Hermida RC, Fernández JR, Mojón A. Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. 2020;37(5):751–8. PMID: 32683989. DOI: 10.1080/07420528.2020.1771356. http://www.ncbi.nlm.nih.gov/pubmed/32683989 +Pubmed +DOI
• Hermida RC, Hermida-Ayala RG, Smolensky M. Chronotherapy for reduction of cardiovascular risk. Med Clin (Barc). 2020;154(12):505–11. PMID: 32336474. DOI: 10.1016/j.medcli.2020.02.004. http://www.ncbi.nlm.nih.gov/pubmed/32336474 +Pubmed +DOI
• Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Crespo JJ, Otero A, Ríos MT, Domínguez-Sardiña M, Fernández JR. Does Timing of Antihypertensive Medication Dosing Matter? Curr Cardiol Rep. 2020;22(10):118. PMID: 32772186. DOI: 10.1007/s11886-020-01353-7. http://www.ncbi.nlm.nih.gov/pubmed/32772186 +Pubmed +DOI
• Hermida RC, Hermida-Ayala RG, Smolensky MH, Mojón A, Fernández JR. Ingestion-time – relative to circadian rhythms – differences in the pharmacokinetics and pharmacodynamics of hypertension medications. Expert Opin Drug Metab Toxicol. 2020 Dec;16(12):1159–73. PMID: 32940072. DOI: 10.1080/17425255.2020.1825681. http://www.ncbi.nlm.nih.gov/pubmed/32940072 +Pubmed +DOI
• Hermida RC, Mojón A, Fernández JR, Hygia Project Investigators. Comparing the design of the primary-care based Hygia Chronotherapy Trial and the Internet-Based TIME Study. Eur Heart J. 2020;41(16):1608. PMID: 32306035. DOI: 10.1093/eurheartj/ehaa276. http://www.ncbi.nlm.nih.gov/pubmed/32306035 +Pubmed +DOI
• Hermida RC, Mojón A, Fernández JR, Otero A, Crespo JJ, Domínguez-Sardiña M, Ríos MT, Smolensky MH. Ambulatory blood pressure monitoring-based definition of true arterial hypertension. Minerva Med. 2020 Dec;111(6):573–88. PMID: 32700870. DOI: 10.23736/S0026-4806.20.06834-2. http://www.ncbi.nlm.nih.gov/pubmed/32700870 +Pubmed +DOI
• Hermida RC, Mojón A, Fernández JR. Ambulatory blood pressure-based inclusion criteria in the Hygia Chronotherapy Trial. Rebuttal to Lemmer and Middeke. Chronobiol Int. 2020;37(8):1270–2. PMID: 32873092. DOI: 10.1080/07420528.2020.1812898. http://www.ncbi.nlm.nih.gov/pubmed/32873092 +Pubmed +DOI
• Hermida RC, Mojón A, Fernández JR. Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials. Chronobiol Int. 2020;37(5):731–8. PMID: 32684008. DOI: 10.1080/07420528.2020.1771354. http://www.ncbi.nlm.nih.gov/pubmed/32684008 +Pubmed +DOI
• Hermida RC, Smolensky MH, Mojón A, Crespo JJ, Ríos MT, Domínguez-Sardiña M, Otero A, Fernández JR. New perspectives on the definition, diagnosis, and treatment of true arterial hypertension. Expert Opin Pharmacother. 2020 Jul;21(10):1167–78. PMID: 32543325. DOI: 10.1080/14656566.2020.1746274. http://www.ncbi.nlm.nih.gov/pubmed/32543325 +Pubmed +DOI

Artigos Científicos

• Hermida RC, Ayala DE, Mojón A, Smolensky MH, Fernández JR. Diagnosis and management of hypertension: around-the-clock ambulatory blood pressure monitoring is substantially more effective and less costly than daytime office blood pressure measurements. Chronobiol Int. 2019;36(11):1515–27. PMID: 31446805. DOI: 10.1080/07420528.2019.1658201. http://www.ncbi.nlm.nih.gov/pubmed/31446805 +Pubmed +DOI
• Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE. Asleep (not night-time) blood pressure as prognostic marker of cardiovascular risk. Eur Heart J. 2019 Mar;40(9):789. PMID: 30561609. DOI: 10.1093/eurheartj/ehy842. http://www.ncbi.nlm.nih.gov/pubmed/30561609 +Pubmed +DOI
• Hermida RC, Hygia Project Investigators. Treatment of sleep-disordered breathing, alone, is insufficient for proper management of sleep-time hypertension. Eur Heart J. 2019;40(38):3208. PMID: 31504433. DOI: 10.1093/eurheartj/ehz606. http://www.ncbi.nlm.nih.gov/pubmed/31504433 +Pubmed +DOI

Artigos Científicos

• Hermida RC, Ayala DE, Fernández JR, Mojón A, Smolensky MH. Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk. Eur J Clin Invest. 2018 May;48(5):e12909. PMID: 29423914. DOI: 10.1111/eci.12909. http://www.ncbi.nlm.nih.gov/pubmed/29423914 +Pubmed +DOI
• Hermida RC, Ayala DE, Mojón A, Fernández JR. Risk of incident chronic kidney disease is better reduced by bedtime than upon-awakening ingestion of hypertension medications. Hypertens Res. 2018 May;41(5):342–53. PMID: 29531290. DOI: 10.1038/s41440-018-0029-1. http://www.ncbi.nlm.nih.gov/pubmed/29531290 +Pubmed +DOI
• Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE, Hygia Project Investigators. Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention. Eur Heart J. 2018 Dec;39(47):4159–71. PMID: 30107515. DOI: 10.1093/eurheartj/ehy475. http://www.ncbi.nlm.nih.gov/pubmed/30107515 +Pubmed +DOI

Artigos Científicos

• Hermida RC, Ayala DE, Fernández JR, Mojón A, Crespo JJ, Ríos MT, Smolensky MH. Bedtime Blood Pressure Chronotherapy Significantly Improves Hypertension Management. Heart Fail Clin. 2017 Oct;13(4):759–73. PMID: 28865783. DOI: 10.1016/j.hfc.2017.05.010. http://www.ncbi.nlm.nih.gov/pubmed/28865783 +Pubmed +DOI
• Hermida RC, Ayala DE, Mojón A, Fernández JR. Sleep-Time Ambulatory BP Is an Independent Prognostic Marker of CKD. J Am Soc Nephrol. 2017 Sep;28(9):2802–11. PMID: 28455314. DOI: 10.1681/ASN.2016111186. http://www.ncbi.nlm.nih.gov/pubmed/28455314 +Pubmed +DOI
• Hermida RC, Ayala DE, Smolensky MH, Fernández JR, Mojón A, Portaluppi F. Sleep-time blood pressure: Unique sensitive prognostic marker of vascular risk and therapeutic target for prevention. Sleep Med Rev. 2017 Jun;33:17–27. PMID: 27316324. DOI: 10.1016/j.smrv.2016.04.001. IF2017: 10.602; D1. http://www.ncbi.nlm.nih.gov/pubmed/27316324 +Pubmed +DOI
• Hermida RC, Smolensky MH, Portaluppi F. Letter by Hermida et al Regarding Article, “The Heart´s Circadian Rhythms Point to Potential Treatment Strategies”. Circulation. 2017 Apr;135(16):e925–6. PMID: 28416530. DOI: 10.1161/CIRCULATIONAHA.116.027056. http://www.ncbi.nlm.nih.gov/pubmed/28416530 +Pubmed +DOI
• Otero-González A, Hermida RC. Control estricto o convencional de la hipertensión arterial en pacientes de alto riesgo cardiovascular, especialmente en la enfermedad renal crónica. NefroPlus. 2017;9(2):112–3. https://www.revistanefrologia.com/es-comentarios-control-estricto-o-convencional-hipertension-arterial-pacientes-alto-riesgo-cardiovascular-articulo-X1888970017620845 Enlace
• Smolensky MH, Hermida RC, Ayala DE, Mojón A, Fernández JR. Bedtime Chronotherapy with Conventional Hypertension Medications to Target Increased Asleep Blood Pressure Results in Markedly Better Chronoprevention of Cardiovascular and Other Risks than Customary On-awakening Therapy. Heart Fail Clin. 2017 Oct;13(4):775–92. PMID: 28865784. DOI: 10.1016/j.hfc.2017.05.011. http://www.ncbi.nlm.nih.gov/pubmed/28865784 +Pubmed +DOI
• Smolensky MH, Hermida RC, Portaluppi F. Circadian mechanisms of 24-hour blood pressure regulation and patterning. Sleep Med Rev. 2017 Jun;33:4–16. PMID: 27076261. DOI: 10.1016/j.smrv.2016.02.003. http://www.ncbi.nlm.nih.gov/pubmed/27076261 +Pubmed +DOI

Artigos Científicos

• Hermida RC, Ayala DE, Mojón A, Fernández JR. Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial. Diabetologia. 2016 Feb;59(2):255–65. PMID: 26399404. DOI: 10.1007/s00125-015-3749-7. http://www.ncbi.nlm.nih.gov/pubmed/26399404 +Pubmed +DOI
• Hermida RC, Ayala DE, Mojón A, Fernández JR. Elevated asleep BP as predictor of type 2 diabetes and therapeutic target for prevention. Diabetologia. 2016 Feb;59(2):392–4. PMID: 26643878. DOI: 10.1007/s00125-015-3833-z. http://www.ncbi.nlm.nih.gov/pubmed/26643878 +Pubmed +DOI
• Hermida RC, Ayala DE, Mojón A, Fernández JR. Sleep-time BP: prognostic marker of type 2 diabetes and therapeutic target for prevention. Diabetologia. 2016 Feb;59(2):244–54. PMID: 26399403. DOI: 10.1007/s00125-015-3748-8. http://www.ncbi.nlm.nih.gov/pubmed/26399403 +Pubmed +DOI
• Hermida RC, Ayala DE, Smolensky MH, Fernández JR, Mojón A, Portaluppi F. Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks. Hypertens Res. 2016 May;39(5):277–92. PMID: 26657008. DOI: 10.1038/hr.2015.142. http://www.ncbi.nlm.nih.gov/pubmed/26657008 +Pubmed +DOI
• Hermida RC, Ayala DE. [Ambulatory blood pressure, chronotherapy of hypertension and glaucoma]. Med Clin (Barc). 2016 Jan;146(1):30–4. PMID: 26228254. DOI: 10.1016/j.medcli.2015.05.013. http://www.ncbi.nlm.nih.gov/pubmed/26228254 +Pubmed +DOI
• Hermida RC. Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project. Chronobiol Int. 2016;33(7):906–36. PMID: 27221952. DOI: 10.1080/07420528.2016.1181078. http://www.ncbi.nlm.nih.gov/pubmed/27221952 +Pubmed +DOI
• Salles GF, Reboldi G, Fagard RH, Cardoso CRL, Pierdomenico SD, Verdecchia P, Eguchi K, Kario K, Hoshide S, Polonia J, de la Sierra A, Hermida RC, Dolan E, O´Brien E, Roush GC, ABC-H Investigators. Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients: The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) Meta-Analysis. Hypertens (Dallas, Tex 1979). 2016 Apr;67(4):693–700. PMID: 26902495. DOI: 10.1161/HYPERTENSIONAHA.115.06981. http://www.ncbi.nlm.nih.gov/pubmed/26902495 +Pubmed +DOI
• Smolensky MH, Hermida RC, Reinberg A, Sackett-Lundeen L, Portaluppi F. Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention. Chronobiol Int. 2016;33(8):1101–19. PMID: 27308960. DOI: 10.1080/07420528.2016.1184678. http://www.ncbi.nlm.nih.gov/pubmed/27308960 +Pubmed +DOI

Capítulos de libro

• Hermida RC, Ayala DE, Smolensky MH, Portaluppi F. Chronotherapy of Blood Pressure Medications to Improve Management of Hypertension and Reduce Vascular Risk. In: Gumz M (ed.). Circadian Clocks: Role in Health and Disease. New York, NY: Springer New York; 2016. p. 295–334. ISBN: 978-1-4939-3450-8. http://link.springer.com/10.1007/978-1-4939-3450-8_11 +DOI
• Hermida RC, Ayala DE. Ambulatory Blood Pressure Monitoring in Special Populations: During Pregnancy. In: White W (ed.). Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Cham: Springer International Publishing; 2016. p. 253–76. ISBN: 978-3-319-22771-9. http://link.springer.com/10.1007/978-3-319-22771-9_13 +DOI
• Smolensky MH, Portaluppi F, Hermida RC. Circadian and Cyclic Environmental Determinants of Blood Pressure Patterning and Implications for Therapeutic Interventions. In: White W (ed.). Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Cham: Springer International Publishing; 2016. p. 105–27. ISBN: 978-3-319-22771-9. http://link.springer.com/10.1007/978-3-319-22771-9_6 +DOI