– Synthesis of new Vitamin D analogs and metabolites. – Design of new synthetic methods for Natural Products. – Development of green synthetic methodologies. – Design and synthesis of new ionic liquids as solvents/catalyst in organic synthesis and other applications. – Development of in silico methodologies for structure-activity and structure-property relationships; bioactive compounds design and toxicophore identification. – Development of new drugs with heterocyclic structure.
Bioorganic Compounds & Ionic Liquids · IIS Galicia Sur
2017
2018
2019
2020
Scientific Papers
Besada P, Gallardo-Gómez M, Pérez-Márquez T, Patiño-Álvarez L, Pantano S, Silva-López C, Terán C, Arévalo-Gómez A, Ruz-Zafra A, Fernández-Martín J, Ortolano S. The New Pharmacological Chaperones PBXs Increase ?-Galactosidase A Activity in Fabry Disease Cellular Models. Biomolecules. 2021;11(12) PMID: 34944500. DOI: 10.3390/biom11121856. http://www.ncbi.nlm.nih.gov/pubmed/34944500 +Pubmed+DOI
Besada P, Viña D, Costas T, Costas-Lago MC, Vila N, Torres-Terán I, Sturlese M, Moro S, Terán C. Pyridazinones containing dithiocarbamoyl moieties as a new class of selective MAO-B inhibitors. Bioorg Chem. 2021;115:105203. PMID: 34371375. DOI: 10.1016/j.bioorg.2021.105203. http://www.ncbi.nlm.nih.gov/pubmed/34371375 +Pubmed+DOI
Ferronato MJ, Nadal Serrano M, Arenas Lahuerta EJ, Bernadó Morales C, Paolillo G, Martinez-Sabadell Aliguer A, Santalla H, Mascaró M, Vitale C, Fall Y, Arribas J, Facchinetti MM, Curino AC. Vitamin D analogues exhibit antineoplastic activity in breast cancer patient-derived xenograft cells. J Steroid Biochem Mol Biol. 2021;208:105735. PMID: 32784045. DOI: 10.1016/j.jsbmb.2020.105735. http://www.ncbi.nlm.nih.gov/pubmed/32784045 +Pubmed+DOI
Scientific Papers
Graña E, Díaz-Tielas C, Sánchez-Moreiras AM, Reigosa MJ, Celeiro M, Abagyan R, Teijeira M, Duke M V, Clerk T, Pan Z, Duke SO. Transcriptome and binding data indicate that citral inhibits single strand DNA-binding proteins. Physiol Plant. 2020 May;169(1):99–109. PMID: 31828797. DOI: 10.1111/ppl.13055. http://www.ncbi.nlm.nih.gov/pubmed/31828797 +Pubmed+DOI
Ribone SR, Ferronato MJ, Vitale C, Fall Y, Curino AC, Facchinetti MM, Quevedo MA. Vitamin D receptor exhibits different pharmacodynamic features in tumoral and normal microenvironments: A molecular modeling study. J Steroid Biochem Mol Biol. 2020;200:105649. PMID: 32142933. DOI: 10.1016/j.jsbmb.2020.105649. http://www.ncbi.nlm.nih.gov/pubmed/32142933 +Pubmed+DOI
Rodríguez-Enríquez F, Costas-Lago MC, Besada P, Alonso-Pena M, Torres-Terán I, Viña D, Fontenla JÁ, Sturlese M, Moro S, Quezada E, Terán C. Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinson´s disease therapy. Bioorg Chem. 2020;104:104203. PMID: 32932120. DOI: 10.1016/j.bioorg.2020.104203. http://www.ncbi.nlm.nih.gov/pubmed/32932120 +Pubmed+DOI
Seck I, Ndoye SF, Ba LA, Fall A, Diop A, Ciss I, Ba A, Sall C, Diop A, Boye CS, Gomez G, Fall Y, Seck M. Access to a Library of 1,3-disubstituted-1,2,3-triazenes and Evaluation of their Antimicrobial Properties. Curr Top Med Chem. 2020;20(9):713–9. PMID: 31985378. DOI: 10.2174/1568026620666200127143005. http://www.ncbi.nlm.nih.gov/pubmed/31985378 +Pubmed+DOI
Scientific Papers
Castiñeira Reis M, López CS, Nieto Faza O, Tantillo DJ. Pushing the limits of concertedness. A waltz of wandering carbocations. Chem Sci. 2019 Feb;10(7):2159–70. PMID: 30881640. DOI: 10.1039/c8sc03567a. http://www.ncbi.nlm.nih.gov/pubmed/30881640 +Pubmed+DOI
Castro-Fernández S, Álvarez-García J, García-Río L, Silva-López C, Cid MM. Double Protonation of a cis-Bipyridoallenophane Detected via Chiral-Sensing Switch: The Role of Ion Pairs. Org Lett. 2019 Aug;21(15):5898–902. PMID: 31329450. DOI: 10.1021/acs.orglett.9b02024. http://www.ncbi.nlm.nih.gov/pubmed/31329450 +Pubmed+DOI
Cerveri A, Faza ON, López CS, Grilli S, Monari M, Bandini M. Phosphine-Catalyzed Stereoselective Dearomatization of 3-NO2-Indoles with Allenoates. J Org Chem. 2019 May;84(10):6347–55. PMID: 31009560. DOI: 10.1021/acs.joc.9b00559. http://www.ncbi.nlm.nih.gov/pubmed/31009560 +Pubmed+DOI
Cid MM, Lago-Silva M, Comesaña MG, Nieto Faza O, López CS. Computational and experimental studies on Cu/Au-catalyzed stereoselective synthesis of 1,3-disubstituted allenes. Org Chem Front. 2019 Jun;6(11):1780–6. DOI: 10.1039/C9QO00364A. https://doi.org/10.1039/C9QO00364A +DOI
Costas-Lago MC, Besada P, Cano E, Terán C. Novel compounds of hybrid structure pyridazinone-coumarin as potent inhibitors of platelet aggregation. Future Med Chem. 2019;11(16):2051–62. PMID: 31538518. DOI: 10.4155/fmc-2018-0373. http://www.ncbi.nlm.nih.gov/pubmed/31538518 +Pubmed+DOI
Ferronato MJ, Obiol DJ, Alonso EN, Guevara JA, Grioli SM, Mascaró M, Rivadulla ML, Martínez A, Gómez G, Fall Y, Quevedo MA, Curino AC, Facchinetti MM. Synthesis of a novel analog of calcitriol and its biological evaluation as antitumor agent. J Steroid Biochem Mol Biol. 2019;185:118–36. PMID: 30125657. DOI: 10.1016/j.jsbmb.2018.08.006. http://www.ncbi.nlm.nih.gov/pubmed/30125657 +Pubmed+DOI
Gómez E, Requejo PF, Tojo E, Macedo EA. Recovery of flavonoids using novel biodegradable choline amino acids ionic liquids based ATPS. Fluid Phase Equilib. 2019 Aug;493:1–9. DOI: 10.1016/j.fluid.2019.03.024. https://linkinghub.elsevier.com/retrieve/pii/S0378381219301372 +DOI
Kosti? M, Verdía P, Fernández?Stefanuto V, Puchta R, Tojo E. A mild and efficient procedure for alkenols oxyselenocyclization by using ionic liquids. J Phys Org Chem. 2019 May;32(5):e3928. DOI: 10.1002/poc.3928. https://onlinelibrary.wiley.com/doi/abs/10.1002/poc.3928 +DOI
Marín-Luna M, Nieto Faza O, Silva López C. Gold-Catalyzed Homogeneous (Cyclo)Isomerization Reactions. Front Chem. 2019;7(APR):296. PMID: 31139614. DOI: 10.3389/fchem.2019.00296. http://www.ncbi.nlm.nih.gov/pubmed/31139614 +Pubmed+DOI
Obiol DJ, Martínez A, Ferronato MJ, Quevedo MA, Grioli SM, Alonso EN, Gómez G, Fall Y, Facchinetti MM, Curino AC. Novel calcitriol analogue with an oxolane group: In vitro, in vivo, and in silico studies. Arch Pharm (Weinheim). 2019 May;352(5):e1800315. PMID: 31025400. DOI: 10.1002/ardp.201800315. http://www.ncbi.nlm.nih.gov/pubmed/31025400 +Pubmed+DOI
Parodi A, Battaglioli S, Liu Y, Monari M, Marín-Luna M, Silva-López C, Bandini M. Scandium catalysed stereoselective thio-allylation of allenyl-imidates. Chem Commun (Camb). 2019 Aug;55(65):9669–72. PMID: 31342026. DOI: 10.1039/c9cc04302k. http://www.ncbi.nlm.nih.gov/pubmed/31342026 +Pubmed+DOI
Rodríguez Fernández CD, Arosa Y, López Lago E, Salgado J, Verdía P, Tojo E, Cabeza O, Varela LM, de la Fuente R. New Insights on the Characterization of the Ionic Liquid Crystal 1-Ethyl-3-Methylimidazolium Decylsulfate. J Phys Chem C. 2019 Dec;123(51):31196–211. DOI: 10.1021/acs.jpcc.9b09660. https://pubs.acs.org/doi/10.1021/acs.jpcc.9b09660 +DOI
Sintra TE, Vilas M, Martins M, Ventura SPM, Lobo Ferreira AIMC, Santos LMNBF, Gonçalves FJM, Tojo E, Coutinho JAP. Synthesis and Characterization of Surface-Active Ionic Liquids Used in the Disruption of Escherichia Coli Cells. Chemphyschem. 2019;20(5):727–35. PMID: 30672638. DOI: 10.1002/cphc.201801127. http://www.ncbi.nlm.nih.gov/pubmed/30672638 +Pubmed+DOI
Terán C, Besada P, Vila N, Costas-Lago MC. Recent advances in the synthesis of phthalazin-1(2H)-one core as a relevant pharmacophore in medicinal chemistry. Eur J Med Chem. 2019 Jan;161:468–78. PMID: 30388463. DOI: 10.1016/j.ejmech.2018.10.047. http://www.ncbi.nlm.nih.gov/pubmed/30388463 +Pubmed+DOI
Vidal Vidal Á, de Vicente Poutás LC, Nieto Faza O, López CS. On the Use of Popular Basis Sets: Impact of the Intramolecular Basis Set Superposition Error. Molecules. 2019 Oct;24(20):1–11. PMID: 31652663. DOI: 10.3390/molecules24203810. http://www.ncbi.nlm.nih.gov/pubmed/31652663 +Pubmed+DOI
Vidal-Vidal Á, Silva López C, Faza ON. Lennard-Jones Intermolecular Potentials for the Description of 6-Membered Aromatic Heterocycles Interacting with the Isoelectronic CO2 and CS2. J Phys Chem A. 2019 May;123(20):4475–85. PMID: 30916964. DOI: 10.1021/acs.jpca.9b00375. http://www.ncbi.nlm.nih.gov/pubmed/30916964 +Pubmed+DOI
Virumbrales C, Solas M, Suárez-Pantiga S, Fernández-Rodríguez MA, Marín-Luna M, López CS, Sanz R. Gold(i)-catalyzed nucleophilic cyclization of ?-monosubstituted o-(alkynyl)styrenes: a combined experimental and computational study. Org Biomol Chem. 2019;17(46):9924–32. PMID: 31720659. DOI: 10.1039/c9ob02126d. http://www.ncbi.nlm.nih.gov/pubmed/31720659 +Pubmed+DOI
Scientific Papers
Ferronato MJ, Alonso EN, Salomón DG, Fermento ME, Gandini NA, Quevedo MA, Mascaró E, Vitale C, Fall Y, Facchinetti MM, Curino AC. Antitumoral effects of the alkynylphosphonate analogue of calcitriol EM1 on glioblastoma multiforme cells. J Steroid Biochem Mol Biol. 2018 Apr;178:22–35. PMID: 29102624. DOI: 10.1016/j.jsbmb.2017.10.019. http://www.ncbi.nlm.nih.gov/pubmed/29102624 +Pubmed+DOI
Book Chapters
Perez-Castillo Y, Sotomayor-Burneo S, Helguera AM, D. S. Cordeiro MN, Tejera E, Pazy- Mino C, Sanchez-Rodriguez A, Moreno MF, Teijeira- Bautista M, Ancede-Gallardo E, Borges F, Cruz- Monteagudo M. Computer-aided Drug Discovery Methodologies in the Modeling of Dual Target Ligands as Potential Parkinson´s Disease Therapeutics. Frontiers in Computational Chemistry (Vol4). 2018. p. 48–90. ISBN: 978-1-68108-441-1. http://www.doi.org/10.2174/9781681084411118040004 +DOI
Sánchez-Moreiras AM, Graña E, Díaz-Tielas C, López-González D, Araniti F, Celeiro M, Teijeira M, Verdeguer M, Reigosa MJ. Elucidating the Phytotoxic Potential of Natural Compounds. In: Sánchez-Moreiras AM, Reigosa MJ (eds.). Advances in Plant Ecophysiology Techniques. Cham: Springer International Publishing; 2018. p. 363–78. ISBN: 978-3-319-93233-0. https://doi.org/10.1007/978-3-319-93233-0_22 +DOI
Teijeira M, Celeiro M. SAR/QSAR. In: Sánchez-Moreiras AM, Reigosa MJ (eds.). Advances in Plant Ecophysiology Techniques. Cham: Springer International Publishing; 2018. p. 347–61. ISBN: 978-3-319-93233-0. https://doi.org/10.1007/978-3-319-93233-0_21 +DOI
Scientific Papers
Belorusova AY, Martínez A, Gándara Z, Gómez G, Fall Y, Rochel N. Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain. Eur J Med Chem. 2017 Jul;134:86–96. PMID: 28399453. DOI: 10.1016/j.ejmech.2017.03.081. IF2017: 4.816; D1. http://www.ncbi.nlm.nih.gov/pubmed/28399453 +Pubmed+DOI
Canoa P, Rivadulla ML, Popplewell J, van Oosten R, Gómez G, Fall Y. Use of surface plasmon resonance in the binding study of vitamin D, metabolites and analogues with vitamin D binding protein. Anal Bioanal Chem. 2017 Apr;409(10):2547–58. PMID: 28116494. DOI: 10.1007/s00216-017-0200-6. IF2017: 3.307; Q1. http://www.ncbi.nlm.nih.gov/pubmed/28116494 +Pubmed+DOI
Costas-Lago MC, Besada P, Rodríguez-Enríquez F, Viña D, Vilar S, Uriarte E, Borges F, Terán C. Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors. Eur J Med Chem. 2017 Oct;139:1–11. PMID: 28797881. DOI: 10.1016/j.ejmech.2017.07.045. IF2017: 4.816; D1. http://www.ncbi.nlm.nih.gov/pubmed/28797881 +Pubmed+DOI
De Deurwaerdère P, Binda C, Corne R, Leone C, Valeri A, Valoti M, Ramsay RR, Fall Y, Marco-Contelles J. Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine. ACS Chem Neurosci. 2017 May;8(5):1026–35. PMID: 27977122. DOI: 10.1021/acschemneuro.6b00377. IF2017: 4.211; Q1. http://www.ncbi.nlm.nih.gov/pubmed/27977122 +Pubmed+DOI
García-Garabal S, Vila J, Rilo E, Domínguez-Pérez M, Segade L, Tojo E, Verdía P, Varela LM, Cabeza O. TRANSPORT PROPERTIES FOR 1-ETHYL-3-METHYLIMIDAZOLIUM n-ALKYL SULFATES: POSSIBLE EVIDENCE OF GROTTHUSS MECHANISM. Electrochim Acta. 2017 Mar;231:94–102. DOI: 10.1016/j.electacta.2017.01.197. IF2017: 5.116; Q1. http://linkinghub.elsevier.com/retrieve/pii/S0013468617302499 +DOI
Graña E, Costas-Gil A, Longueira S, Celeiro M, Teijeira M, Reigosa MJ, Sánchez-Moreiras AM. Auxin-like effects of the natural coumarin scopoletin on Arabidopsis cell structure and morphology. J Plant Physiol. 2017 Nov;218:45–55. DOI: 10.1016/j.jplph.2017.07.007. IF2017: 2.833; Q1. http://linkinghub.elsevier.com/retrieve/pii/S017616171730189X +DOI
Marco-Contelles J, Fall Y. Editorial: Multitarget Molecules for Alzheimer´s Disease Therapy. Curr Top Med Chem. 2017 Feb;17(31):3318. PMID: 29500890. DOI: 10.2174/156802661731180221110409. IF2017: 3.374; Q2. http://www.ncbi.nlm.nih.gov/pubmed/29500890 +Pubmed+DOI
Martínez A, Santalla H, Garrido F, Gómez G, Fall Y. Modified Julia olefination and ? aminoxylation reactions mediated convergent synthesis of 1?, 24 ( R )-dihydroxyvitamin D 3 (tacalcitol). Tetrahedron Lett. 2017 Sep;58(36):3568–70. DOI: 10.1016/j.tetlet.2017.07.103. IF2017: 2.125; Q2. http://linkinghub.elsevier.com/retrieve/pii/S0040403917309735 +DOI
Santalla H, Faza ON, Gómez G, Fall Y, Silva López C. From Hydrindane to Decalin: A Mild Transformation through a Dyotropic Ring Expansion. Org Lett. 2017 Jul;19(13):3648–51. PMID: 28641016. DOI: 10.1021/acs.orglett.7b01621. IF2017: 6.492; D1. http://www.ncbi.nlm.nih.gov/pubmed/28641016 +Pubmed+DOI
Santalla H, Martínez A, Garrido F, Gómez G, Fall Y. An improved methodology for the synthesis of 1?,25-dihydroxy-20-epi-vitamin D 3 (MC 1288) and Gemini analog Ro-438-3582. Org Chem Front. 2017;4(10):1999–2001. DOI: 10.1039/C7QO00381A. IF2017: 5.455; D1. http://xlink.rsc.org/?DOI=C7QO00381A +DOI
Verdía P, González EJ, Moreno D, Palomar J, Tojo E. Deepening of the Role of Cation Substituents on the Extractive Ability of Pyridinium Ionic Liquids of N-Compounds from Fuels. ACS Sustain Chem Eng. 2017 Feb;5(2):2015–25. DOI: 10.1021/acssuschemeng.6b02922. IF2017:6.140; D1. http://pubs.acs.org/doi/10.1021/acssuschemeng.6b02922 +DOI
Scientific Papers
Ferronato MJ, Alonso EN, Gandini NA, Fermento ME, Villegas ME, Quevedo MA, Arévalo J, López Romero A, Rivadulla ML, Gómez G, Fall Y, Facchinetti MM, Curino AC. The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression. J Steroid Biochem Mol Biol. 2016 Oct;163:193–205. PMID: 27208626. DOI: 10.1016/j.jsbmb.2016.05.019. IF2016: 4.561; Q1. http://www.ncbi.nlm.nih.gov/pubmed/27208626 +Pubmed+DOI
Helguera AM, Perez-Castillo Y, D S Cordeiro MN, Tejera E, Paz-Y-Miño C, Sánchez-Rodríguez A, Teijeira M, Ancede-Gallardo E, Cagide F, Borges F, Cruz-Monteagudo M. Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2AAdenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors. Curr Pharm Des. 2016 May;22(21):3082–96. PMID: 26932160. DOI: 10.2174/1381612822666160302103542. IF2016: 2.611; Q2. http://www.ncbi.nlm.nih.gov/pubmed/26932160 +Pubmed+DOI
Rocha MAA, Vilas M, Rodrigues ASMC, Tojo E, Santos LMNBF. Physicochemical properties of 2-alkyl-1-ethylpyridinium based ionic liquids. Fluid Phase Equilib. 2016 Nov;428:112–20. DOI: 10.1016/j.fluid.2016.05.030. IF2016: 2.473; Q2. http://linkinghub.elsevier.com/retrieve/pii/S0378381216302734 +DOI
Saíz-Urra L, Teijeira M, Rivero-Buceta V, Helguera AM, Celeiro M, Terán MC, Besada P, Borges F. Topological sub-structural molecular design (TOPS-MODE): a useful tool to explore key fragments of human A3 adenosine receptor ligands. Mol Divers. 2016 Feb;20(1):55–76. PMID: 26205409. DOI: 10.1007/s11030-015-9617-z. IF2016: 1.752; Q2. http://www.ncbi.nlm.nih.gov/pubmed/26205409 +Pubmed+DOI
Santamarta F, Vilas M, Tojo E, Fall Y. Synthesis and properties of novel chiral imidazolium-based ionic liquids derived from carvone. RSC Adv. 2016;6(37):31177–80. DOI: 10.1039/C6RA00654J. IF2016: 3.108; Q2. http://pubs.rsc.org/-/content/articlelanding/2016/ra/c6ra00654j/unauth#!divAbstract +DOI
Vila N, Besada P, Viña D, Sturlese M, Moro S, Terán C. Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors. RSC Adv. 2016 Apr;6(52):46170–85. DOI: 10.1039/C6RA03841G. IF2016: 3.108; Q2. http://xlink.rsc.org/?DOI=C6RA03841G +DOI
Scientific Papers
Azuaje J, Pérez-Rubio JM, Yaziji V, El Maatougui A, González-Gomez JC, Sánchez-Pedregal VM, Navarro-Vázquez A, Masaguer CF, Teijeira M, Sotelo E. Integrated Ugi-based assembly of functionally, skeletally, and stereochemically diverse 1,4-benzodiazepin-2-ones. J Org Chem. 2015 Feb;80(3):1533–49. PMID: 25560990. DOI: 10.1021/jo502382q. IF2015: 4.785; Q1. http://pubs.acs.org/doi/abs/10.1021/jo502382q +Pubmed+DOI
Costas T, Costas-Lago MC, Vila N, Besada P, Cano E, Terán C. New platelet aggregation inhibitors based on pyridazinone moiety. Eur J Med Chem. 2015 Apr;94:113–22. PMID: 25757094. DOI: 10.1016/j.ejmech.2015.02.061. IF2015: 3.902; Q1. http://www.ncbi.nlm.nih.gov/pubmed/25757094 +Pubmed+DOI
Ferronato MJ, Obiol DJ, Fermento ME, Gandini NA, Alonso EN, Salomón DG, Vitale C, Mascaró E, Fall Y, Raimondi AR, Curino AC, Facchinetti MM. The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer. J Steroid Biochem Mol Biol. 2015 Nov;154:285–93. PMID: 26365558. DOI: 10.1016/j.jsbmb.2015.09.009. IF2015: 3.985; Q1. http://www.ncbi.nlm.nih.gov/pubmed/26365558 +Pubmed+DOI
Ferronato MJ, Salomón DG, Fermento ME, Gandini NA, López Romero A, Rivadulla ML, Pérez-García X, Gómez G, Pérez M, Fall Y, Facchinetti MM, Curino AC. Vitamin D analogue: potent antiproliferative effects on cancer cell lines and lack of hypercalcemic activity. Arch Pharm (Weinheim). 2015 May;348(5):315–29. PMID: 25864390. DOI: 10.1002/ardp.201400448. IF2015: 2.043; Q2Q3. http://doi.wiley.com/10.1002/ardp.201400448 +Pubmed+DOI
Lorenzo M, Vilas M, Verdía P, Villanueva M, Salgado J, Tojo E. Long-term thermal stabilities of ammonium ionic liquids designed as potential absorbents of ammonia. RSC Adv. 2015;5(51):41278–84. DOI: 10.1039/C5RA03192C. IF2015: 3.289; Q2. http://xlink.rsc.org/?DOI=C5RA03192C +DOI
Mahrova M, Pagano F, Pejakovic V, Valea A, Kalin M, Igartua A, Tojo E. Pyridinium based dicationic ionic liquids as base lubricants or lubricant additives. Tribol Int. 2015 Feb;82:245–54. DOI: 10.1016/j.triboint.2014.10.018. IF2015: 2.259; Q1. http://linkinghub.elsevier.com/retrieve/pii/S0301679X14003752 +DOI
Pazó M, Zúñiga A, Pérez M, Gómez G, Fall Y. Total synthesis of (+)-decytospolides A and B. Tetrahedron Lett. 2015 Jun;56(24):3774–6. DOI: 10.1016/j.tetlet.2015.04.055. IF2015: 2.347; Q2. http://linkinghub.elsevier.com/retrieve/pii/S0040403915006929 +DOI
Vila N, Besada P, Costas T, Costas-Lago MC, Terán C. Phthalazin-1(2H)-one as a remarkable scaffold in drug discovery. Eur J Med Chem. 2015 Jun;97:462–82. PMID: 25482553. DOI: 10.1016/j.ejmech.2014.11.043. IF2015: 3.902; Q1. http://www.ncbi.nlm.nih.gov/pubmed/25482553 +Pubmed+DOI
Vilas M, González EJ, Tojo E. Extractive denitrogenation of model oils with tetraalkyl substituted pyridinium based ionic liquids. Fluid Phase Equilib. 2015 Jun;396:66–73. DOI: 10.1016/j.fluid.2015.03.032. IF2015: 1.846; Q2. http://linkinghub.elsevier.com/retrieve/pii/S0378381215001545 +DOI
Vilas M, Rocha MAA, Fernandes AM, Tojo E, Santos LMNBF. Novel 2-alkyl-1-ethylpyridinium ionic liquids: synthesis, dissociation energies and volatility. Phys Chem Chem Phys. 2015 Jan;17(4):2560–72. PMID: 25493639. DOI: 10.1039/c4cp05191b. IF2015: 4.449; Q1. http://www.ncbi.nlm.nih.gov/pubmed/25493639 +Pubmed+DOI
Scientific Papers
Di Giovanni G, García I, Colangeli R, Pierucci M, Rivadulla ML, Soriano E, Chioua M, Della Corte L, Yáñez M, De Deurwaerdère P, Fall Y, Marco-Contelles J. N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA): A potential cognitive enhancer with MAO inhibitor properties. CNS Neurosci Ther. 2014 Jul;20(7):633–40. PMID: 24848125. DOI: 10.1111/cns.12284. IF: 3.931; Q1. http://www.ncbi.nlm.nih.gov/pubmed/24848125 +Pubmed+DOI
Díaz M, Ortiz A, Vilas M, Tojo E, Ortiz I. Performance of PEMFC with new polyvinyl-ionic liquids based membranes as electrolytes. Int J Hydrogen Energy. 2014 Mar;39(8):3970–7. DOI: 10.1016/j.ijhydene.2013.04.155. IF: 3.313; Q1. http://linkinghub.elsevier.com/retrieve/pii/S0360319913011336 +DOI
García I, Fall Y, Gomez G. Editorial (Thematic Issue: New Synthetic Strategies to Vitamin D Analogues). Curr Top Med Chem. 2014 Dec;14(21):2367–2367. PMID: 25537067. DOI: 10.2174/1568026615666141208105941. IF: 3.402; Q1. http://www.ncbi.nlm.nih.gov/pubmed/25537067 +Pubmed+DOI
Pazos G, Pérez M, Gándara Z, Gómez G, Fall Y. Synthesis of a chiral building block for highly functionalized polycyclic ethers. Org Biomol Chem. 2014 Oct;12(39):7750–7. PMID: 25144156. DOI: 10.1039/c4ob01439a. IF: 3.562; Q1. http://www.ncbi.nlm.nih.gov/pubmed/25144156 +Pubmed+DOI
Verdía P, Hernaiz M, González EJ, Macedo EA, Salgado J, Tojo E. Effect of the number, position and length of alkyl chains on the physical properties of polysubstituted pyridinium ionic liquids. J Chem Thermodyn. 2014 Feb;69:19–26. DOI: 10.1016/j.jct.2013.09.028. IF: 2.679; Q2. http://linkinghub.elsevier.com/retrieve/pii/S0021961413003479 +DOI
Code
RTC2019-006826-1 Z039
Title
Desarrollo de Nuevos Medicamentos basados en análogos de VIT D para el tratamiento de la deficiencia de Vitamina D y patologías asociadas ?
Funder
Ministerio de Ciencia e Innovación
Type
Individual
Duration
2020 – 2022
PI
Yagamare Fall Diop
Cols.
F. Garrido. H. Santalla. M. Gómez
Code
RTI2018-093695-J-I00
Title
Estudio del modo de acción y el potencial bioherbicida de compuestos naturales con actividad fitotóxica
Funder
Ministerio de Ciencia Innovación y Universidades
Type
Individual
Duration
2019 – 2021
PI
Adela Sánchez Moreiras (External PI)
Cols.
M. Teijeira
Code
ED431E 2018/07
Title
Cluster de Investigación e Transferencia Agroalimentario do Campus da Auga (CITACA)
Funder
Axencia Galega de Innovación
Type
Multicéntrico
Duration
2018 – 2020
PI
Ana Torrado Agrasar (External PI)
Cols.
C. Silva. M. Gómez. O. Nieto. Y. Fall
Code
ED431C 2017/70
Title
Axudas consolidación grupos de referencia competitiva
Funder
Axencia Galega de Innovación
Type
Individual
Duration
2018 – 2020
PI
María Magdalena Cid (External PI)
Cols.
C. Silva. F. Garrido. H. Santalla. M. Gómez. O. Nieto. Y. Fall
Code
AGL2013-41281-R
Title
Metabolitos secundarios como bioherbicidas potenciales. Una alternativa sostenible en el control de las malas hierbas
Funder
Ministerio de Economía y Competitividad
Type
Individual
Duration
2014 – 2016
PI
Adela M Sánchez Moreiras (External PI)
Cols.
M. Teijeira
Code
CM 1206 EXIL
Title
EXIL – Exchange on Ionic Liquids
Funder
Comisión Europea
Type
Coordinado
Duration
2013 – 2017
PI
Dr. Anja-Verena Mudring (External PI)
Coordinator
Dr. Anja-Verena Mudring (Coord. Inorganic Chemistry III Ruhr-Universität Bochum, Germany)
Cols.
E. Tojo
Code
CN 2012/184
Title
Consolidación y estructuración de unidades de investigación competitivas del sistema universitario de Galicia
Funder
Consellería de Cultura, Educación e Ordenación Universitaria
Type
Individual
Duration
2012 – 2014
PI
Mª del Carmen Terán Moldes
Title
Desarrollo de nuevos líquidos iónicos y otras sales relacionadas para una química sostenible
Obtención de precursores del anillo A modificados en el C-1 y de análogos de la vitamina D modificados en la cadena lateral. Síntesis de nuevos análogos de esteroides
Obtención enantio selectiva de oxaciclos y polioxaciclos, con potencial actividad biológica y desarrollo de nuevos métodos de síntesis de compuestos heterocíclicos
Compuesto químico, procedimiento de obtención y uso. Preparation of an imidazolium chiral ionic liquid derived from proline and its use as catalyst in the one pot synthesis of the (S)-Hajos dione
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