SYNAPSE – IISGS

Research Leader(s)

Rosa Mª Martínez Rolán

MD, PhD Neurosurgery
rosa.maria.martinez.rolan@sergas.es

Collaborating Researchers

Adolfo De la Lama Zaragoza

MD Neurosurgery
adolfo.ramon.de.la.lama.zaragoza@sergas.es

Álvaro Martín Gallego

MD, PhD Neurosurgery
alvaro.martin.gallego@sergas.es

Cesáreo Miguel Conde Alonso

MD, PhD, HoS Neurosurgery
cesareo.miguel.conde.alonso@sergas.es

Eva Azevedo González

MD Neurosurgery
eva.azevedo.gonzalez@sergas.es

Lara González Gómez

MD Neurosurgery
Lara.Maria.Gonzalez.Gomez@sergas.es

Pablo Sanroman Álvarez

MD Neurosurgery
pablo.sanroman.alvarez@sergas.es

Pablo Sousa Casasnovas

MD Neurosurgery
Pablo.Sousa.Casasnovas@sergas.es

Pedro Miguel González Vargas

MD Neurosurgery
Pedro.Miguel.Gonzalez.Vargas@sergas.es

Tamara Cao Cardero

MD Neurosurgery
Tamara.Cao.Cardero@sergas.es

Resident Researchers

Antía Domínguez Núñez

MD Neurosurgery
Antia.Dominguez.Nunez@sergas.es

Lourdes Calero Félix

MD Neurosurgery
Lourdes.Calero.Felix@sergas.es

External Collaborators

Jose Luis Thenier Vila

MD Neurosurgery

Hospital Universitario Arnau de Vilanova

– Development of Phase II clinical studies on new drugs for cerebral concussion
– Development of clinical studies on new drugs for cerebral metastases

2017

2018

2019

2020

Scientific Papers

Zhu L, Retana D, García-Gómez P, Álvaro-Espinosa L, Priego N, Masmudi-Martín M, Yebra N, Miarka L, Hernández-Encinas E, Blanco-Aparicio C, Martínez S, Sobrino C, Ajenjo N, Artiga M-J, Ortega-Paino E, Torres-Ruiz R, Rodríguez-Perales S, RENACER, Soffietti R, Bertero L, Cassoni P, Weiss T, Muñoz J, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Laín A, Toldos O, Ruano Y, Alcázar L, Blasco G, Fernández-Alén J, Caleiras E, Lafarga M, Megías D, Graña-Castro O, Nör C, Taylor MD, Young LS, Varešlija D, Cosgrove N, Couch FJ, Cussó L, Desco M, Mouron S, Quintela-Fandino M, Weller M, Pastor J, Valiente M, RENACER (Adolfo de la Lama-Zaragoza; Lourdes Calero-Felix). A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. EMBO Mol Med. 2022;14(3):e14552. PMID: 35174975. DOI: 10.15252/emmm.202114552. http://www.ncbi.nlm.nih.gov/pubmed/35174975 +Pubmed +DOI

Scientific Papers

González-Vargas PM, Calero Félix L, Martín-Gallego Á, Thenier-Villa JL, de la Lama Zaragoza AR, Conde Alonso C. Evaluation of the implantation of transpedicular screws in spinal instrumentation with free-hand technique and navigation-assisted with intraoperative computed tomography: An analytical-positional study. Neurocir (English Ed. 2021 Mar;(E-PUB) PMID: 33663907. DOI: 10.1016/j.neucir.2021.01.001. http://www.ncbi.nlm.nih.gov/pubmed/33663907 +Pubmed +DOI
Solo-Peleteiro A, Diéguez P, Pérez-Rodríguez MT, Galárraga RA, Pérez-Landeiro A, Álvarez-Fernández M. Cerebrospinal fluid drainage-related ventriculitis due to multidrug-resistant microorganisms. Enfermedades Infecc y Microbiol Clin (English ed). 2021 Feb;(E-PUB) PMID: 33593611. DOI: 10.1016/j.eimc.2020.12.010. http://www.ncbi.nlm.nih.gov/pubmed/33593611 +Pubmed +DOI

Scientific Papers

Diaz-Molina J, Martínez R, González-Vargas P, Calero L, Azevedo A, Conde C. Tisseel® versus Hemopatch® for dural sealing in neurosurgery. A prospective study in a tertiary center. Neurochirurgie. 2020 Dec;66(6):429–34. PMID: 33091461. DOI: 10.1016/j.neuchi.2020.09.008. http://www.ncbi.nlm.nih.gov/pubmed/33091461 +Pubmed +DOI
González-Vargas PM, Thenier-Villa JL, Calero Félix L, Galárraga Campoverde RA, Martín-Gallego Á, de la Lama Zaragoza A, Conde Alonso CM. Factors that negatively influence the Glasgow Outcome Scale in patients with chronic subdural hematomas. An analytical and retrospective study in a tertiary center. Interdiscip Neurosurg. 2020 Jun;20:100606. DOI: 10.1016/j.inat.2019.100606. https://doi.org/10.1016/j.inat.2019.100606%0A +DOI
González-Vargas PM, Thenier-Villa JL, Sanromán Álvarez P, Serantes Combo A, Calero Félix L, Galárraga Campoverde RA, Azevedo González E, Martín-Gallego Á, Martínez-Rolan R, de la Lama Zaragoza A, Conde Alonso C. Hemangiopericytoma/Solitary Fibrous Tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center. Neurocir (English Ed. 2020 Jan;31(1):14–23. PMID: 31351895. DOI: 10.1016/j.neucir.2019.06.001. http://www.ncbi.nlm.nih.gov/pubmed/31351895 +Pubmed +DOI
Simal-Julián JA, Miranda-Lloret P, Pérez de San Román Mena L, Sanromán-Álvarez P, García-Piñero A, Sanchis-Martín R, Botella-Asunción C, Kassam A. Impact of Multilayer Vascularized Reconstruction after Skull Base Endoscopic Endonasal Approaches. J Neurol Surg B Skull Base. 2020 Apr;81(2):128–35. PMID: 32206530. DOI: 10.1055/s-0039-1677705. http://www.ncbi.nlm.nih.gov/pubmed/32206530 +Pubmed +DOI
Thenier-Villa JL, Riveiro Rodríguez A, González-Vargas PM, Martínez-Rolán RM, Gelabert-González M, Badaoui Fernández A, Pou J, Conde Alonso C. Effects of external ventricular drainage decompression of intracranial hypertension on rebleeding of brain aneurysms: A fluid structure interaction study. Interdiscip Neurosurg. 2020 Mar;19:100613. DOI: 10.1016/j.inat.2019.100613. https://doi.org/10.1016/j.inat.2019.100613%0A +DOI

Scientific Papers

Galarraga-Campoverde R, Thenier-Villa JL, Lantier A, Gonzalez-Vargas PM, Calero-Felix L, de la Lama-Zaragoza A, Conde-Alonso C. [Intraoperative intracerebral tension pneumocephalus secondary to hydrogen peroxide as a hemostatic agent]. Rev Neurol. 2019;68(2):89–90. PMID: 30638259. http://www.ncbi.nlm.nih.gov/pubmed/30638259 +Pubmed
Thenier-Villa JL, Riveiro Rodríguez A, Martínez-Rolán RM, Gelabert-González M, González-Vargas PM, Calero-Félix L, Galarraga Campoverde RA, De La Lama Zaragoza AR, Pou J, Alonso CC. A1 asynchrony, a potential risk factor for the rupture of anterior communicating artery aneurysms: A computational fluid dynamics study. Neurocirugia (Astur). 2019;30(5):207–14. PMID: 31155281. DOI: 10.1016/j.neucir.2019.04.002. http://www.ncbi.nlm.nih.gov/pubmed/31155281 +Pubmed +DOI

Scientific Papers

González P, Thenier J, Galárraga R, de la Lama A, Azevedo E, Conde C. Persistent extra-axial post-surgical collections and Propionibacterium acnes infection. Presentation of two cases and literature review. Neurocir (English Ed. 2018 May;29(3):150–6. PMID: 29033263. DOI: 10.1016/j.neucir.2017.09.004. http://www.ncbi.nlm.nih.gov/pubmed/29033263 +Pubmed +DOI
González-Vargas P, Thenier-Villa JL, Serantes Combo A, González García J, Azevedo González E, Díaz Molina J, Galárraga Campoverde R, Calero Félix L, de la Lama Zaragoza A. Dorsal meningioma and subdural hematoma in a patient without risk factors for anticoagulation. Description of a very atypical case and review of the literature. Interdiscip Neurosurg. 2018 Dec;14:142–6. DOI: 10.1016/j.inat.2018.08.001. https://doi.org/10.1016/j.inat.2018.08.001 %0A +DOI
Thenier-Villa JL, González-Vargas PM, De La Lama Zaragoza AR, Conde Alonso C. Hidrocefalia postraumática e higromas subdurales en pacientes con traumatismo craneoencefálico moderado y severo: diferencias entre hemicraniectomía descompresiva. Neurol Argentina. 2018 Oct;10(4):202–9. DOI: 10.1016/j.neuarg.2018.06.003. https://doi.org/10.1016/j.neuarg.2018.06.003 +DOI
Thenier-Villa JL, Riveiro Rodríguez A, Martínez-Rolán RM, Gelabert-González M, González-Vargas PM, Galarraga Campoverde RA, Díaz Molina J, De La Lama Zaragoza A, Martínez-Cueto P, Pou J, Conde Alonso C. Hemodynamic Changes in the Treatment of Multiple Intracranial Aneurysms: A Computational Fluid Dynamics Study. World Neurosurg. 2018 Oct;118:e631–8. PMID: 30017759. DOI: 10.1016/j.wneu.2018.07.009. http://www.ncbi.nlm.nih.gov/pubmed/30017759 +Pubmed +DOI
Thenier-Villa JL, Sanromán-Álvarez P, Miranda-Lloret P, Plaza Ramírez ME. Incomplete reossification after craniosynostosis surgery-incidence and analysis of risk factors: a clinical-radiological assessment study. J Neurosurg Pediatr. 2018 Aug;22(2):120–7. PMID: 29799353. DOI: 10.3171/2018.2.PEDS17717. http://www.ncbi.nlm.nih.gov/pubmed/29799353 +Pubmed +DOI

Scientific Papers

Sanromán-Álvarez P, Simal-Julián JA, García-Piñero A, Miranda-Lloret P. Multitask Box Trainer for Endoscopic Endonasal Skull Base Surgery: ENDOtrainer. World Neurosurg. 2017 May;101:304–7. PMID: 28232211. DOI: 10.1016/j.wneu.2017.02.008. http://www.ncbi.nlm.nih.gov/pubmed/28232211 +Pubmed +DOI
Thenier-Villa JL, Galárraga-Campoverde RA, Martínez Rolán RM, De La Lama Zaragoza AR, Martínez Cueto P, Muñoz Garzón V, Salgado Fernández M, Conde Alonso C. Linear Accelerator Stereotactic Radiosurgery of Central Nervous System Arteriovenous Malformations: A 15-Year Analysis of Outcome-Related Factors in a Single Tertiary Center. World Neurosurg. 2017 Jul;103:291–302. PMID: 28435119. DOI: 10.1016/j.wneu.2017.04.081. IF2017: 1.924; Q2. http://www.ncbi.nlm.nih.gov/pubmed/28435119 +Pubmed +DOI
Thenier-Villa JLJL, Alejandro Galárraga Campoverde R, Ramón DE LA Lama Zaragoza A, Conde Alonso CC, Alejandro Galarraga Campoverde R, Ramon DE LA Lama Zaragoza A, Conde Alonso CC. Predictors of Morbidity and Cleavage Plane in Surgical Resection of Pure Convexity Meningiomas Using Cerebrospinal Fluid Sensitive Image Subtraction Magnetic Resonance Imaging. Neurol Med Chir (Tokyo). 2017 Jan;57(1):35–43. PMID: 27580930. DOI: 10.2176/nmc.oa.2016-0169. http://www.ncbi.nlm.nih.gov/pubmed/27580930 +Pubmed +DOI

Code

252BN201

Adolfo De la Lama Zaragoza

Title

Estudio Fase 2, multicéntrico, doble ciego, multidosis, controlado con placebo, randomizado y de grupos paralelos para evaluar la eficacia y seguridad de BIIB093 intravenoso en pacientes con contusión cerebral

Start date

2019

Sponsor

BIOGEN IDEC RESEARCH LTD.

Title

Geometric and hemodynamic analysis of the risk of rupture of intracranial aneurysms

URL

https://www.educacion.gob.es/teseo/mostrarRef.do?ref=1845444

Author

Jose Luis Thenier Villa

Supervisor

Rosa Mª Martínez Rolán

External supervisor(s)/co-supervisor(s)

Antonio Riveiro Rodríguez

University

Universidad de Santiago de Compostela

Date

23/10/2020