Nephro-Proteomics

Research Leader(s)

Alfonso Otero González

MD, PhD Nephrology
ALFONSO.OTERO.GONZALEZ@SERGAS.ES

Predoctoral Researchers

Elena Iglesias Lamas

MD Nephrology
elena.iglesias.lamas@sergas.es

Juan José Bravo López

MD Nephrology
juan.jose.bravo.lopez@sergas.es

Resident Researchers

Beatriz Ferreiro Álvarez

MD Nephrology
beatriz.ferreiro.alvarez@sergas.es

External Collaborators

Hugo Miguel Baptista Carreira dos Santos

BChem, PhD Applied Chemistry

Universidad Nova de Lisboa (Portugal

Chronic kidney disease
Glomerulonephritis
Proteomics
Peritoneal dialysis
Ageing

– URINARY PROTEOMICS AND CHRONIC KIDNEY DISEASE. Contribution of urinary proteomics to the study of podocyte disease associated with ageing.
– PROTEOMICS AND LIQUID RENAL BIOPSY. Comprehensive study of protein content in plasma, urine and tissue of patients with glomerular nephropathy
– PROTEOMIC ANALYSIS OF DIALYSATE LIQUID IN PERITONEAL DIALYSIS. Vitamin D-Binding Protein (DBP) and Alfa2-HS Glycoprotein in peritoneal effluent (EP). Analysis of correlation with vascular calcification and insulin resistance in patients in peritoneal dialysis.

2017

2018

2019

2020

Scientific Papers

Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Mojón A, Fernández JR, Hermida RC. Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials. Chronobiol Int. 2020 Jul;37(5):771–80. PMID: 32684071. DOI: 10.1080/07420528.2020.1781351. http://www.ncbi.nlm.nih.gov/pubmed/32684071 +Pubmed +DOI
Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ. The Hygia Project and Hygia Chronotherapy Trial: insights of we clinical investigators on the impact of the embedded continuing medical education on primary-care practice and improved patient cardiovascular health. Chronobiol Int. 2020;37(5):759–66. PMID: 32684006. DOI: 10.1080/07420528.2020.1771357. http://www.ncbi.nlm.nih.gov/pubmed/32684006 +Pubmed +DOI
Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE, Hygia Project Investigators. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020 Oct;41(48):4565–76. PMID: 31641769. DOI: 10.1093/eurheartj/ehz754. http://www.ncbi.nlm.nih.gov/pubmed/31641769 +Pubmed +DOI
Hermida RC, Mojón A, Fernández JR, Otero A, Crespo JJ, Domínguez-Sardiña M, Ríos MT, Smolensky MH. Ambulatory blood pressure monitoring-based definition of true arterial hypertension. Minerva Med. 2020 Dec;111(6):573–88. PMID: 32700870. DOI: 10.23736/S0026-4806.20.06834-2. http://www.ncbi.nlm.nih.gov/pubmed/32700870 +Pubmed +DOI
Hermida RC, Smolensky MH, Mojón A, Crespo JJ, Ríos MT, Domínguez-Sardiña M, Otero A, Fernández JR. New perspectives on the definition, diagnosis, and treatment of true arterial hypertension. Expert Opin Pharmacother. 2020 Jul;21(10):1167–78. PMID: 32543325. DOI: 10.1080/14656566.2020.1746274. http://www.ncbi.nlm.nih.gov/pubmed/32543325 +Pubmed +DOI

Scientific Papers

Cavero T, Arjona E, Soto K, Caravaca-Fontán F, Rabasco C, Bravo L, de la Cerda F, Martín N, Blasco M, Ávila A, Huerta A, Cabello V, Jarque A, Alcázar C, Fulladosa X, Carbayo J, Anaya S, Cobelo C, Ramos N, Iglesias E, Baltar J, Martínez-Gallardo R, Pérez L, Morales E, González R, Macía M, Draibe J, Pallardó L, Quintana LF, Espinosa M, Barros X, Pereira F, Cao M, Moreno JA, Rodríguez de Córdoba S, Praga M, Spanish Group for the Study of Glomerular Diseases (GLOSEN). Severe and malignant hypertension are common in primary atypical hemolytic uremic syndrome. Kidney Int. 2019;96(4):995–1004. PMID: 31420192. DOI: 10.1016/j.kint.2019.05.014. http://www.ncbi.nlm.nih.gov/pubmed/31420192 +Pubmed +DOI
Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE. Asleep (not night-time) blood pressure as prognostic marker of cardiovascular risk. Eur Heart J. 2019 Mar;40(9):789. PMID: 30561609. DOI: 10.1093/eurheartj/ehy842. http://www.ncbi.nlm.nih.gov/pubmed/30561609 +Pubmed +DOI

Scientific Papers

Fernandez-Juarez G, Perez JV, Caravaca-Fontán F, Quintana L, Shabaka A, Rodriguez E, Gadola L, de Lorenzo A, Cobo MA, Oliet A, Sierra M, Cobelo C, Iglesias E, Blasco M, Galeano C, Cordon A, Oliva J, Praga M, Spanish Group for the Study of Glomerular Diseases (GLOSEN). Duration of Treatment with Corticosteroids and Recovery of Kidney Function in Acute Interstitial Nephritis. Clin J Am Soc Nephrol. 2018 Dec;13(12):1851–8. PMID: 30397027. DOI: 10.2215/CJN.01390118. http://www.ncbi.nlm.nih.gov/pubmed/30397027 +Pubmed +DOI
Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE, Hygia Project Investigators. Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention. Eur Heart J. 2018 Dec;39(47):4159–71. PMID: 30107515. DOI: 10.1093/eurheartj/ehy475. http://www.ncbi.nlm.nih.gov/pubmed/30107515 +Pubmed +DOI
Otero González A, de Francisco ALM, Gayoso P, López FG. Obesity and renal function. Data from the epidemiological study: Prevalence of chronic renal disease in Spain. EPIRCE Study. Nefrologia. 2018 Jan;38(1):107–8. PMID: 29325670. DOI: 10.1016/j.nefro.2017.03.015. http://www.ncbi.nlm.nih.gov/pubmed/29325670 +Pubmed +DOI

Scientific Papers

DaSilva I, Huerta A, Quintana L, Redondo B, Iglesias E, Draibe J, Praga M, Ballarin J, Diaz-Encarnacion M. Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. BioDrugs. 2017 Jun;31(3):239–49. PMID: 28534103. DOI: 10.1007/s40259-017-0221-x. IF2017: 3.824; Q1. https://www.ncbi.nlm.nih.gov/pubmed/28534103 +Pubmed +DOI
Pérez Melón C, Ferreiro Álvarez B, Iglesias Lamas E, Camba Caride MJ, Borrajo Prol MP, Novoa Fernández E. Enterococcus gallinarum and Chilaiditi syndrome in peritoneal dialysis. Nefrologia. Sociedad Española de Nefrología; 2017 Mar;37(2):213–4. PMID: 27707577. DOI: 10.1016/j.nefro.2016.09.001. IF2017: 1.167; Q4. http://www.ncbi.nlm.nih.gov/pubmed/27707577 +Pubmed +DOI

Scientific Papers

Brück K, Jager KJ, Dounousi E, Kainz A, Nitsch D, Ärnlöv J, Rothenbacher D, Browne G, Capuano V, Ferraro PM, Ferrieres J, Gambaro G, Guessous I, Hallan S, Kastarinen M, Navis G, Otero Gonzalez A, Palmieri L, Romundstad S, Spoto B, Stengel B, Tomson C, Tripepi G, Völzke H, Wiecek A, Gansevoort R, Schöttker B, Wanner C, Vinhas J, Zoccali C, Van Biesen W, Stel VS, Wi?cek A, Gansevoort R, Schöttker B, Wanner C, Vinhas J, Zoccali C, Van Biesen W, Stel VS, European CKD Burden Consortium. Erratum: Methodology used in studies reporting chronic kidney disease prevalence: A systematic literature review (Nephrology Dialysis Transplantation (2015) 30:4 (iv6-iv16) DOI:10.1093/NDT/gfv131). Nephrol Dial Transplant. 2016 Apr;31(4):680. PMID: 26908763. DOI: 10.1093/ndt/gfw024. http://www.ncbi.nlm.nih.gov/pubmed/26908763 +Pubmed +DOI
Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, Kastarinen M, Guessous I, Vinhas J, Stengel B, Brenner H, Chudek J, Romundstad S, Tomson C, Otero-González A, Bello AK, Ferrieres J, Palmieri L, Browne G, Capuano V, Van Biesen W, Zoccali C, Gansevoort R, Navis G, Rothenbacher D, Ferraro PM, Nitsch D, Wanner C, Jager KJ, European CKD Burden Consortium. CKD Prevalence Varies across the European General Population. J Am Soc Nephrol. 2016 Jul;27(7):2135–47. PMID: 26701975. DOI: 10.1681/ASN.2015050542. IF2016: 8.966; D1. http://www.ncbi.nlm.nih.gov/pubmed/26701975 +Pubmed +DOI
Pérez Melón C, Borrajo Prol M, Iglesias E, Ferreiro B, Camba Caride M. Daptomycin in peritoneal dialysis, intraperitoneal or intravenous. Nefrologia. 2016 Jul;36(4):461–2. PMID: 26680497. DOI: 10.1016/j.nefro.2015.11.001. IF2016: 1.183; Q4. http://www.ncbi.nlm.nih.gov/pubmed/26680497 +Pubmed +DOI

Scientific Papers

Brück K, Jager KJ, Dounousi E, Kainz A, Nitsch D, Ärnlöv J, Rothenbacher D, Browne G, Capuano V, Ferraro PM, Ferrieres J, Gambaro G, Guessous I, Hallan S, Kastarinen M, Navis G, Gonzalez AO, Palmieri L, Romundstad S, Spoto B, Stengel B, Tomson C, Tripepi G, Völzke H, Wi?cek A, Gansevoort R, Schöttker B, Wanner C, Vinhas J, Zoccali C, Van Biesen W, Stel VS, European CKD Burden Consortium. Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review. Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv6-16. PMID: 26209739. DOI: 10.1093/ndt/gfv131. IF2014: 3.577; Q1. http://www.ncbi.nlm.nih.gov/pubmed/26209739 +Pubmed +DOI
Otero Gonzalez A, Prol MPB, Caride MJC, Nores JS, Novoa E, Melon CP, Macia P, Alves MT, Cid M, Osorio E, Coto E, Macias Nuñez JF. Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people. Int Urol Nephrol. 2015 Aug;47(8):1403–8. PMID: 26152646. DOI: 10.1007/s11255-015-1041-x. IF2014: 1.519; Q3. http://www.ncbi.nlm.nih.gov/pubmed/26152646 +Pubmed +DOI

Scientific Papers

Araújo JE, Oliveira E, Otero-Glez A, Santos Nores J, Igrejas G, Lodeiro C, Capelo JL, Santos HM. A comprehensive factorial design study of variables affecting protein extraction from formalin-fixed kidney tissue samples. Talanta. 2014 Feb;119:90–7. PMID: 24401389. DOI: 10.1016/j.talanta.2013.10.019. IF: 3.545; Q1. http://www.ncbi.nlm.nih.gov/pubmed/24401389 +Pubmed +DOI
Oliveira E, Araújo JE, Gómez-Meire S, Lodeiro C, Perez-Melon C, Iglesias-Lamas E, Otero-Glez A, Capelo JL, Santos HM. Proteomics analysis of the peritoneal dialysate effluent reveals the presence of calcium-regulation proteins and acute inflammatory response. Clin Proteomics. 2014;11(1):17. PMID: 24742231. DOI: 10.1186/1559-0275-11-17. IF: N/A. http://www.ncbi.nlm.nih.gov/pubmed/24742231 +Pubmed +DOI

Code

PI15/01467

Title

Acción estratégica en Galicia para la poliquistosis renal: establecimiento de un registro gallego y diagnóstico genético como una

Funder

Instituto de Salud Carlos III

Type

Multicéntrico

Duration

2016 – 2018

Miguel García González (External PI)

Cols.

A. Otero

Code

PI13/02031

Title

Función renal (FR) y marcadores de inflamación en relación con mortalidad, eventos cardiovasculares y deterioro de FR. Estudio de cohortes en población general adulta: EPIRCE II.

Funder

Instituto de Salud Carlos III

Type

Multicéntrico

Duration

2014 – 2016

Pilar Gayoso Diz (External PI)

Cols.

A. Otero

Code

MoTHER HDx

Alfonso Otero González

Title

Estudio multicéntrico, abierto, prospectivo, aleatorizado para explorar la morbimortalidad en pacientes dializados con hemodiálisis extendida en comparación con la hemodiafiltración en línea

Start date

2019

Sponsor

Sociedad Española de Nefrología

Code

DOPPS 6

Alfonso Otero González

Title

Dialysis Outcomes and Practice Patterns Study

Start date

2016

Sponsor

Arbor Research Collaborative for Health

Code

ABC-TREAT

Alfonso Otero González

Title

Estudio prospectivo aleatorizado multicéntrico para demostrar los beneficios de la HD sin acetato (con citrato)

Start date

2016

Sponsor

FUNDACION SENEFRO

Title

Las pruebas diagnósticas desde la perspectiva poblacional: epidemiología de la enfermedad renal crónica y la resistencia a la insulina

URL

https://www.educacion.gob.es/teseo/mostrarRef.do?ref=1072065

Author

Pilar Gayoso Diz

Supervisor

Alfonso Otero González

External supervisor(s)/co-supervisor(s)

Arturo Gonzalez Quintela y Francisco Gude Sampedro

University

Universidad Santiago de Compostela

Date

17/06/2013

Title

UTILIDAD TERAPEUTICA DE LA HEMOFILTRACION VENO-VENOSA CONTINUA Y DEPURACION DE CITOKINAS EN EL SINDROME DE DISTRES RESPIRATORIO DEL ADULTO “

Author

Carmen Casas Garcia

Supervisor

Alfonso Otero González

Co-Supervisor

Alfonso Otero González

External supervisor(s)/co-supervisor(s)

JR Gonzalez Juanatey

University

santiago de compostela

Date

15/06/2003