SYNAPSE

Psico-neuro-endocrinología, Metabolismo y Enfermedades Raras

Principales líneas de investigación

  • Desarrollo de estudios clínicos en Fase II, sobre nuevos fármacos para contusiones cerebrales.
  • Desarrollo de estudios clínicos sobre nuevos fármacos para metástasis cerebrales

Investigadores Responsables

Rosa Mª Martínez Rolán
Rosa Mª Martínez Rolán
MD, PhD, HoS Neurocirugía

Investigadores Colaboradores

Adolfo De la Lama Zaragoza
Adolfo De la Lama Zaragoza
MD Neurocirugía
Pablo Sanroman Álvarez
Pablo Sanroman Álvarez
MD Neurocirugía
Pedro Miguel González Vargas
Pedro Miguel González Vargas
MD Neurocirugía

Colaboradores Externos

Jose Luis Thenier Vila
Jose Luis Thenier Vila
MD Neurocirugía

Artículos Científicos

Rodrigues-Gomes RM, Martinez Rolan R, Botana-Rial M, Del Rio Gonzalez A,Aran-Echabe E. Expiratory Flow Bias and Physiological Effects of Rapid ChestCompression in Mechanically Ventilated Neurocritical Patients: A SecondaryAnalysis of a Randomized Controlled Trial. J Clin Med. 2025 Sep 16;14(18):6516.doi: 10.3390/jcm14186516. PubMed PMID: 41010720; PubMed Central PMCID:PMC12471280.


Rodrigues-Gomes RM, Prieto Campo A, Martinez Rolan R, Gelabert-Gonzalez M.Effects of rapid chest compression technique on intracranial and cerebralperfusion pressures in acute neurocritical patients: a randomized controlledtrial. Crit Care. 2025 Apr 23;29(1):159. doi: 10.1186/s13054-025-05405-8. PubMedPMID: 40270039; PubMed Central PMCID: PMC12020190.


Artículos Científicos

Rodrigues Gomes RM, Martínez Rolán RM, Gelabert González M. Efectos de la compresión torácica rápida en la presión intracraneal en paciente con hemorragia subaracnoidea: caso clínico. Fisioterapia. 2024;46(3):158-61.


Artículos Científicos

Rodrigues-Gomes RM, Lage Cendon L, Martinez Rolan R, Gelabert-Gonzalez M.Respiratory physiotherapy as a tool to allow and optimize lung donation. RespirMed Case Rep. 2023 Oct 8;46:101917. doi: 10.1016/j.rmcr.2023.101917. eCollection2023. PubMed PMID: 37860584; PubMed Central PMCID: PMC10582771.


Libros / Capítulos de libros

Sanromán Álvarez P, González Vargas PM, de la Lama Zaragoza AR, Conde Alonso CM. Transoral Endoscopic Resection of High Cervical Osteophytes. En: Endoscopy of the Spine: Principle and Practice. Springer Nature; 2023. pp. 129-33.


Artículos Científicos

Castano-Leon AM, Paredes I, Lagares A, Gomez PA, Gonzalez-Leon P, Perez-NunezA, Jimenez-Roldan L, Delgado-Fernandez J, Eiriz Fernandez C, Garcia-Perez D,Moreno-Gomez LM, Esteban-Sinovas O, Delgado-Lopez PD, Martin-Alonso J, Kaen A,Tirado-Caballero J, Ordonez-Carmona M, Arteaga-Romero F, Gonzalez-Pombo M, F AlenJ, Gil-Simoes R, Torres CV, Navas-Garcia M, Blasco Garcia de Andoain G,Frade-Porto N, Gonzalez-Tarno P, Martin Segura A, Gelabert-Gonzalez M,Menendez-Cortezon B, Rodriguez-Botana B, Perez-Alfayate R, Fernandez-Garcia C,Ferrandez-Pujante B, Vargas-Jimenez AC, Cotua C, de la Lama A, Calero Felix L,Ruiz-Juretschke F, Garcia-Leal R, Valera-Mele M,(…) Sistiaga-Gracia IL, Zabalo G. Patients awaitingsurgery for neurosurgical diseases during the first wave of the COVID-19 pandemicin Spain: a multicentre cohort study. BMJ Open. 2022 Aug 17;12(8):e061208. doi:10.1136/bmjopen-2022-061208. PubMed PMID: 35977759; PubMed Central PMCID:PMC9388715.


Rodrigues-Gomes RM, Marti JD, Rolan RM, Gelabert-Gonzalez M. Rapid chestcompression effects on intracranial pressure in patients with acute cerebralinjury. Trials. 2022 Apr 15;23(1):312. doi: 10.1186/s13063-022-06189-w. PubMedPMID: 35428364; PubMed Central PMCID: PMC9012060.


Rubinan P, Perez-Rodriguez MT, Dominguez A, Sousa A, Lima O, Rubianes M, CondeC, Alvarez-Fernandez M. Oral sequential therapy in the treatment of post-surgicalepidural abscess and subdural empyema. Infection. 2022 Oct;50(5):1385-1389. doi:10.1007/s15010-022-01814-x. Epub 2022 Apr 23. PubMed PMID: 35460496.


Solo-Peleteiro A, Dieguez P, Perez-Rodriguez MT, Galarraga RA, Perez-LandeiroA, Alvarez-Fernandez M. Cerebrospinal fluid drainage-related ventriculitis due tomultidrug-resistant microorganisms. Enferm Infecc Microbiol Clin (Engl Ed). 2022Jun-Jul;40(6):322-325. doi: 10.1016/j.eimce.2020.12.005. PubMed PMID: 35680350.


Zhu L, Retana D, Garcia-Gomez P, Alvaro-Espinosa L, Priego N, Masmudi-MartinM, Yebra N, Miarka L, Hernandez-Encinas E, Blanco-Aparicio C, Martinez S, SobrinoC, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodriguez-Perales S;RENACER; Soffietti R, Bertero L, Cassoni P, Weiss T, Munoz J, Sepulveda JM,Gonzalez-Leon P, Jimenez-Roldan L, Moreno LM, Esteban O, Perez-Nunez A,Hernandez-Lain A, Toldos O, Ruano Y, Alcazar L, Blasco G, Fernandez-Alen J,Caleiras E, Lafarga M, Megias D, Grana-Castro O, Nor C, Taylor MD, Young LS,Vareslija D, Cosgrove N, Couch FJ, Cusso L, Desco M, Mouron S, Quintela-FandinoM, Weller M, Pastor J, Valiente M, RENACER COLLABORATORS (Adolfo De la Lama Zaragoza). A clinically compatible drug-screeningplatform based on organotypic cultures identifies vulnerabilities to prevent andtreat brain metastasis. EMBO Mol Med. 2022 Mar 7;14(3):e14552. doi:10.15252/emmm.202114552. Epub 2022 Feb 17. PubMed PMID: 35174975; PubMed CentralPMCID: PMC8899920.
Enlace


Artículos Científicos

Calero-Félix L, González-Vargas PM, Castro Vilanova MD, Fernández Pérez MJ, Pérez Rodríguez MT, de la Lama Zaragoza AR, et al. Lymphocytic meningitis due to mediterranean botanical fever. About a case [Meningitis linfocitaria por fiebre botonosa mediterránea. A propósito de un caso]. Neurologia Argentina. 2021;13(3):188-91.


González – Vargas PM, Calero Félix L, Thenier-Villa JL, Domínguez Núñez A, de la Lama Zaragoza A, Alonso CC. Anaplastic Pilocytic Astrocytoma in adults: A comprehensive literature review based on 2 clinical cases. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. Elsevier B.V.; 2021;25.


González-Vargas PM, Calero Félix L, Martín-Gallego Á, Thenier-Villa JL, de la Lama Zaragoza AR, Conde Alonso C. Evaluation of the implantation of transpedicular screws in spinal instrumentation with free-hand technique and navigation-assisted with intraoperative computed tomography: An analytical-positional study. Neurocir (English Ed. 2021 Mar;(E-PUB) PMID: 33663907. DOI: 10.1016/j.neucir.2021.01.001. http://www.ncbi.nlm.nih.gov/pubmed/33663907
Enlace


Paredes I, Castano Leon AM, Lagares A, Jimenez Roldan L, Perez-Nunez A,Gonzalez-Leon P, Delgado-Fernandez J, Eiriz C, Garcia-Perez D, Moreno-Gomez LM,Esteban-Sinovas O, Delgado-Lopez P, Martin-Alonso J, Kaen A, Tirado-Caballero J,Ordonez Carmona M, Arteaga Romero F, Gonzalez Pombo M, Alen JF, Gil-Simoes R,Torres CV, Navas Garcia M, Blasco G, Frade-Porto N, Gonzalez-Tarno P, MartinSegura A, Gelabert-Gonzalez M, Menendez Cortezon B, Rodriguez Botana B,Perez-Alfayate R, Fernandez Garcia C, Ferrandez Pujante B, Vargas-Jimenez A,Cotua C, de la Lama A, Calero L, Ruiz-Juretschke F (…) Zabalo San Juan G. Impact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: a nationwide study in Spain. BMJ Open. 2021. Dec 10;11(12):e053983. doi: 10.1136/bmjopen-2021-053983. PubMed PMID: 34893486;PubMed Central PMCID: PMC9065769.


Artículos Científicos

Arikan F, Errando N, Lagares A, Gandara D, Gabarros A, Lopez-Ojeda P, IbanezJ, Brell M, Gomez PA, Fernandez-Alen JA, Morera J, Horcajadas A, Vanaclocha V,Llacer JL, Bano-Ruiz E, Goncalves-Estella JM, Torne R, Hoyos JA, Sarabia R,Arrese I, Rodriguez-Boto G, de la Lama A, Dominguez J, Martin-Laez R,Santamarta-Gomez D, Delgado-Lopez PD, Ley-Urzaiz L, Mateo O, Iza B,Orduna-Martinez J, de Asis Lorente-Munoz F, Munoz-Hernandez F, Iglesias J,Vilalta J. Variability of Clinical and Angiographic Results Based on theTreatment Preference (Endovascular or Surgical) of Centers Participating in theSubarachnoid Hemorrhage Database of the Working Group of the Spanish Society ofNeurosurgery. World Neurosurg. 2020 Mar;135:e339-e349. doi:10.1016/j.wneu.2019.11.163. Epub 2019 Dec 5. PubMed PMID: 31811967.


Diaz-Molina J, Martínez R, González-Vargas P, Calero L, Azevedo A, Conde C. Tisseel® versus Hemopatch® for dural sealing in neurosurgery. A prospective study in a tertiary center. Neurochirurgie. 2020 Dec;66(6):429–34. PMID: 33091461. DOI: 10.1016/j.neuchi.2020.09.008. http://www.ncbi.nlm.nih.gov/pubmed/33091461
Enlace


González-Vargas PM, Thenier-Villa JL, Calero Félix L, Galárraga Campoverde RA, Martín-Gallego Á, de la Lama Zaragoza A, Conde Alonso CM. Factors that negatively influence the Glasgow Outcome Scale in patients with chronic subdural hematomas. An analytical and retrospective study in a tertiary center. Interdiscip Neurosurg. 2020 Jun;20:100606. DOI: 10.1016/j.inat.2019.100606. https://doi.org/10.1016/j.inat.2019.100606%0A
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González-Vargas PM, Thenier-Villa JL, Sanromán Álvarez P, Serantes Combo A, Calero Félix L, Galárraga Campoverde RA, Azevedo González E, Martín-Gallego Á, Martínez-Rolan R, de la Lama Zaragoza A, Conde Alonso C. Hemangiopericytoma/Solitary Fibrous Tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center. Neurocir (English Ed. 2020 Jan;31(1):14–23. PMID: 31351895. DOI: 10.1016/j.neucir.2019.06.001. http://www.ncbi.nlm.nih.gov/pubmed/31351895
Enlace


Simal-Julián JA, Miranda-Lloret P, Pérez de San Román Mena L, Sanromán-Álvarez P, García-Piñero A, Sanchis-Martín R, Botella-Asunción C, Kassam A. Impact of Multilayer Vascularized Reconstruction after Skull Base Endoscopic Endonasal Approaches. J Neurol Surg B Skull Base. 2020 Apr;81(2):128–35. PMID: 32206530. DOI: 10.1055/s-0039-1677705. http://www.ncbi.nlm.nih.gov/pubmed/32206530
Enlace


Thenier-Villa JL, Riveiro Rodríguez A, González-Vargas PM, Martínez-Rolán RM, Gelabert-González M, Badaoui Fernández A, Pou J, Conde Alonso C. Effects of external ventricular drainage decompression of intracranial hypertension on rebleeding of brain aneurysms: A fluid structure interaction study. Interdiscip Neurosurg. 2020 Mar;19:100613. DOI: 10.1016/j.inat.2019.100613. https://doi.org/10.1016/j.inat.2019.100613%0A
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Artículos Científicos

Galarraga-Campoverde R, Thenier-Villa JL, Lantier A, Gonzalez-Vargas PM, Calero-Felix L, de la Lama-Zaragoza A, Conde-Alonso C. [Intraoperative intracerebral tension pneumocephalus secondary to hydrogen peroxide as a hemostatic agent]. Rev Neurol. 2019;68(2):89–90. PMID: 30638259. http://www.ncbi.nlm.nih.gov/pubmed/30638259
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Thenier-Villa JL, Riveiro Rodríguez A, Martínez-Rolán RM, Gelabert-González M, González-Vargas PM, Calero-Félix L, Galarraga Campoverde RA, De La Lama Zaragoza AR, Pou J, Alonso CC. A1 asynchrony, a potential risk factor for the rupture of anterior communicating artery aneurysms: A computational fluid dynamics study. Neurocirugia (Astur). 2019;30(5):207–14. PMID: 31155281. DOI: 10.1016/j.neucir.2019.04.002. http://www.ncbi.nlm.nih.gov/pubmed/31155281
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Artículos Científicos

González P, Thenier J, Galárraga R, de la Lama A, Azevedo E, Conde C. Persistent extra-axial post-surgical collections and Propionibacterium acnes infection. Presentation of two cases and literature review. Neurocir (English Ed. 2018 May;29(3):150–6. PMID: 29033263. DOI: 10.1016/j.neucir.2017.09.004. http://www.ncbi.nlm.nih.gov/pubmed/29033263
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González-Vargas P, Thenier-Villa JL, Serantes Combo A, González García J, Azevedo González E, Díaz Molina J, Galárraga Campoverde R, Calero Félix L, de la Lama Zaragoza A. Dorsal meningioma and subdural hematoma in a patient without risk factors for anticoagulation. Description of a very atypical case and review of the literature. Interdiscip Neurosurg. 2018 Dec;14:142–6. DOI: 10.1016/j.inat.2018.08.001. https://doi.org/10.1016/j.inat.2018.08.001 %0A
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Thenier-Villa JL, González-Vargas PM, De La Lama Zaragoza AR, Conde Alonso C. Hidrocefalia postraumática e higromas subdurales en pacientes con traumatismo craneoencefálico moderado y severo: diferencias entre hemicraniectomía descompresiva. Neurol Argentina. 2018 Oct;10(4):202–9. DOI: 10.1016/j.neuarg.2018.06.003. https://doi.org/10.1016/j.neuarg.2018.06.003
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Thenier-Villa JL, Riveiro Rodríguez A, Martínez-Rolán RM, Gelabert-González M, González-Vargas PM, Galarraga Campoverde RA, Díaz Molina J, De La Lama Zaragoza A, Martínez-Cueto P, Pou J, Conde Alonso C. Hemodynamic Changes in the Treatment of Multiple Intracranial Aneurysms: A Computational Fluid Dynamics Study. World Neurosurg. 2018 Oct;118:e631–8. PMID: 30017759. DOI: 10.1016/j.wneu.2018.07.009. http://www.ncbi.nlm.nih.gov/pubmed/30017759
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Thenier-Villa JL, Sanromán-Álvarez P, Miranda-Lloret P, Plaza Ramírez ME. Incomplete reossification after craniosynostosis surgery-incidence and analysis of risk factors: a clinical-radiological assessment study. J Neurosurg Pediatr. 2018 Aug;22(2):120–7. PMID: 29799353. DOI: 10.3171/2018.2.PEDS17717. http://www.ncbi.nlm.nih.gov/pubmed/29799353
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Artículos Científicos

Sanromán-Álvarez P, Simal-Julián JA, García-Piñero A, Miranda-Lloret P. Multitask Box Trainer for Endoscopic Endonasal Skull Base Surgery: ENDOtrainer. World Neurosurg. 2017 May;101:304–7. PMID: 28232211. DOI: 10.1016/j.wneu.2017.02.008. http://www.ncbi.nlm.nih.gov/pubmed/28232211
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Thenier-Villa JL, Galárraga-Campoverde RA, Martínez Rolán RM, De La Lama Zaragoza AR, Martínez Cueto P, Muñoz Garzón V, Salgado Fernández M, Conde Alonso C. Linear Accelerator Stereotactic Radiosurgery of Central Nervous System Arteriovenous Malformations: A 15-Year Analysis of Outcome-Related Factors in a Single Tertiary Center. World Neurosurg. 2017 Jul;103:291–302. PMID: 28435119. DOI: 10.1016/j.wneu.2017.04.081. IF2017: 1.924; Q2. http://www.ncbi.nlm.nih.gov/pubmed/28435119
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Thenier-Villa JLJL, Alejandro Galárraga Campoverde R, Ramón DE LA Lama Zaragoza A, Conde Alonso CC, Alejandro Galarraga Campoverde R, Ramon DE LA Lama Zaragoza A, Conde Alonso CC. Predictors of Morbidity and Cleavage Plane in Surgical Resection of Pure Convexity Meningiomas Using Cerebrospinal Fluid Sensitive Image Subtraction Magnetic Resonance Imaging. Neurol Med Chir (Tokyo). 2017 Jan;57(1):35–43. PMID: 27580930. DOI: 10.2176/nmc.oa.2016-0169. http://www.ncbi.nlm.nih.gov/pubmed/27580930
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Título
Geometric and hemodynamic analysis of the risk of rupture of intracranial aneurysms
Doctorando
Jose Luis Thenier Villa
Director
Rosa Mª Martínez Rolán
Universidad
Universidad de Santiago de Compostela
Fecha
23/10/2020
Código
252BN201
IP
Adolfo De la Lama Zaragoza
Título
Estudio Fase 2, multicéntrico, doble ciego, multidosis, controlado con placebo, randomizado y de grupos paralelos para evaluar la eficacia y seguridad de BIIB093 intravenoso en pacientes con contusión cerebral
Inicio
2019
Promotor
BIOGEN IDEC RESEARCH LTD.