– Role of ion channels in neuronal behavior – Use of electrophysiological techniques, mainly “patch-Clamp”, combined with pharmacological, molecular and immunocytochemical techniques. – Determination of ion channel types involved in maintaining the resting membrane potential and study of the spike frequency adaptation of neurons from the autonomic nervous system in culture. At present, our main focus are the two-pore-domain potassium channels (K2P), given that we have recently demonstrated for the first time that these channels are well expressed at the sympathetic nervous system. Notwithstanding, we are also interested in other potassium, sodium or cationic channels. – Development of the central nervous system: study of the development of the different encephalic compartments and the spinal cord in vertebrates, from an evolutive point of view.
Armas-Capote N, Maglio LE, Pérez-Atencio L, Martin-Batista E, Reboreda A, Barios JA, Hernandez G, Alvarez de la Rosa D, Lamas JA, Barrio LC, Giraldez T. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures. Cereb Cortex. 2020 May;30(5):3184–97. PMID: 31819941. DOI: 10.1093/cercor/bhz302. http://www.ncbi.nlm.nih.gov/pubmed/31819941 +Pubmed+DOI
Diz-Chaves Y, Herrera-Pérez S, González-Matías LC, Lamas JA, Mallo F. Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress. Nutrients. 2020 Oct;12(11):3304. PMID: 33126672. DOI: 10.3390/nu12113304. http://www.ncbi.nlm.nih.gov/pubmed/33126672 +Pubmed+DOI
Gefaell J, Prieto T, Abdelaziz M, Álvarez I, Antón J, Arroyo J, Bella JL, Botella M, Bugallo A, Claramonte V, Gijón J, Lizarte E, Maroto RM, Megías M, Milá B, Ramón C, Vila M, Rolán-Alvarez E. Acceptance and knowledge of evolutionary theory among third-year university students in Spain, PLoS One. 2020; 15:e0238345. doi: 10.1371/journal.pone.0238345. +Pubmed+DOI
Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A, McIntosh JM. Expression of ?3?2?4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists. J Neurochem. 2020 Jul;154(2):158–76. PMID: 31967330. DOI: 10.1111/jnc.14966. http://www.ncbi.nlm.nih.gov/pubmed/31967330 +Pubmed+DOI
Rivas-Ramírez P, Reboreda A, Rueda-Ruzafa L, Herrera-Pérez S, Lamas JA. Contribution of KCNQ and TREK Channels to the Resting Membrane Potential in Sympathetic Neurons at Physiological Temperature. Int J Mol Sci. 2020 Aug;21(16) PMID: 32806753. DOI: 10.3390/ijms21165796. http://www.ncbi.nlm.nih.gov/pubmed/32806753 +Pubmed+DOI
Rivas-Ramírez P, Reboreda A, Rueda-Ruzafa L, Herrera-Pérez S, Lamas JA. PIP2 Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons. Int J Mol Sci. 2020 Jan;21(2):ref. 389. PMID: 31936257. DOI: 10.3390/ijms21020389. http://www.ncbi.nlm.nih.gov/pubmed/31936257 +Pubmed+DOI
Scientific Papers
Lamas JA, Fernández-Fernández D. Tandem pore TWIK-related potassium channels and neuroprotection. Neural Regen Res. 2019 Aug;14(8):1293–308. PMID: 30964046. DOI: 10.4103/1673-5374.253506. http://www.ncbi.nlm.nih.gov/pubmed/30964046 +Pubmed+DOI
Lamas JA, Rueda-Ruzafa L, Herrera-Pérez S. Ion Channels and Thermosensitivity: TRP, TREK, or Both? Int J Mol Sci. 2019 May;20(10) PMID: 31091651. DOI: 10.3390/ijms20102371. http://www.ncbi.nlm.nih.gov/pubmed/31091651 +Pubmed+DOI
Pombal MA, Megías M. Development and Functional Organization of the Cranial Nerves in Lampreys. Anat Rec (Hoboken). 2019;302(3):512–39. PMID: 29659164. DOI: 10.1002/ar.23821. http://www.ncbi.nlm.nih.gov/pubmed/29659164 +Pubmed+DOI
Rueda-Ruzafa L, Cruz F, Roman P, Cardona D. Gut microbiota and neurological effects of glyphosate. Neurotoxicology. 2019;75:1–8. PMID: 31442459. DOI: 10.1016/j.neuro.2019.08.006. http://www.ncbi.nlm.nih.gov/pubmed/31442459 +Pubmed+DOI
Scientific Papers
Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Lamas JA. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. Obukhov AG (ed.). PLoS One. 2018 Jun;13(6):e0199282. PMID: 29928032. DOI: 10.1371/journal.pone.0199282. http://www.ncbi.nlm.nih.gov/pubmed/29928032 +Pubmed+DOI
Roman P, Rueda-Ruzafa L, Cardona D, Cortes-Rodríguez A. Gut-brain axis in the executive function of austism spectrum disorder. Behav Pharmacol. 2018;29(7):654–63. PMID: 30179883. DOI: 10.1097/FBP.0000000000000428. http://www.ncbi.nlm.nih.gov/pubmed/30179883 +Pubmed+DOI
Book Chapters
Rueda-Ruzafa L, Requena Mullor M. Miembro Inferior. Miología. In: Carmona Mena D, Román López P (eds.). Manual de prácticas de anatomía humana. Universidad de Almería; 2018. p. 68–80. ISBN: 978-84-17261-30-6. ISBN: 978-84-17261-30-6. https://books.google.es/books?id=OaJxDwAAQBAJ&pg=PA3&source=gbs_toc_r&cad=3#v=onepage&q&f=false Link
Rueda-Ruzafa L, Requena Mullor M. Miembro Inferior. Miología. In: Carmona Mena D, Román López P (eds.). Manual de prácticas de anatomía humana. Universidad de Almería; 2018. p. 68–80. ISBN: 978-84-17261-30-6. ISBN: 978-84-17261-30-6. https://books.google.es/books?id=OaJxDwAAQBAJ&pg=PA3&source=gbs_toc_r&cad=3#v=onepage&q&f=false Link
Rueda-Ruzafa L, Requena Mullor M. Miembro Inferior. Miología. In: Carmona Mena D, Román López P (eds.). Manual de prácticas de anatomía humana. Universidad de Almería; 2018. p. 68–80. ISBN: 978-84-17261-30-6. ISBN: 978-84-17261-30-6. https://books.google.es/books?id=OaJxDwAAQBAJ&pg=PA3&source=gbs_toc_r&cad=3#v=onepage&q&f=false Link
Scientific Papers
Cal L, MegÍas M, Cerdá-Reverter JM, Postlethwait JH, Braasch I, Rotllant J. BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. J Exp Zool B Mol Dev Evol. 2017 Nov;328(7):697–708. PMID: 28544213. DOI: 10.1002/jez.b.22748. IF2017: 2.432; Q1. http://www.ncbi.nlm.nih.gov/pubmed/28544213 +Pubmed+DOI
Hone AJ, Michael McIntosh J, Rueda-Ruzafa L, Passas J, de Castro-Guerín C, Blázquez J, González-Enguita C, Albillos A. Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells. J Neurochem. 2017;140(1):37–52. PMID: 27805736. DOI: 10.1111/jnc.13883. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220418/pdf/nihms827870.pdf +Pubmed+DOI
Rodríguez-Alonso R, Megías M, Pombal MA, Molist P. Morphological and functional aspects of the epidermis of the sea lamprey Petromyzon marinus throughout development. J Fish Biol. 2017 Jul;91(1):80–100. PMID: 28543020. DOI: 10.1111/jfb.13330. IF2017: 1.702; Q2. http://www.ncbi.nlm.nih.gov/pubmed/28543020 +Pubmed+DOI
Suarez-Bregua P, Chien C-J, Megias M, Du S, Rotllant J. Promoter architecture and transcriptional regulation of musculoskeletal embryonic nuclear protein 1b ( mustn1b ) gene in zebrafish. Dev Dyn. 2017 Dec;246(12):992–1000. PMID: 28891223. DOI: 10.1002/dvdy.24591. IF2017: 2.507; Q1. http://www.ncbi.nlm.nih.gov/pubmed/28891223 +Pubmed+DOI
Scientific Papers
Pérez-Fernández J, Megías-Pacheco M, Pombal Diego MÁ. Expression of a Novel D4 Dopamine Receptor in the Lamprey Brain. Evolutionary Considerations about Dopamine Receptors. Front Neuroanat. 2016 Jan;9:165. PMID: 26778974. DOI: 10.3389/fnana.2015.00165. IF2015: 3.260; D1. http://www.ncbi.nlm.nih.gov/pubmed/26778974 +Pubmed+DOI
Scientific Papers
Álvarez Nogal R, Molist-García P. The outer mantle epithelium of Haliotis tuberculata (Gastropoda Haliotidae): an ultrastructural and histochemical study using lectins. Acta Zool. 2015 Oct;96(4):452–9. DOI: 10.1111/azo.12090. IF2015: 0.989; Q3. http://doi.wiley.com/10.1111/azo.12090 +DOI
Ellison A, Rodríguez López CM, Moran P, Breen J, Swain M, Megías-Pacheco M, Hegarty M, Wilkinson M, Pawluk R, Consuegra S. Epigenetic regulation of sex ratios may explain natural variation in self-fertilization rates. Proceedings Biol Sci. 2015 Nov;282:20151900. PMID: 26559950. DOI: 10.1098/rspb.2015.1900. IF2015: 4.823; Q1. http://www.ncbi.nlm.nih.gov/pubmed/26559950 +Pubmed+DOI
Rivas-Ramírez P, Adaveira-Mosquera A, Lamas-Castro JA, Reboreda-Prieto A. Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons. Eur J Neurosci. 2015 Jul;42(2):1797–807. PMID: 25899939. DOI: 10.1111/ejn.12930. IF2015: 2.975; Q2. http://www.ncbi.nlm.nih.gov/pubmed/25899939 +Pubmed+DOI
Scientific Papers
Pérez-Fernández J, Megías M, Pombal MA. Cloning, phylogeny, and regional expression of a Y5 receptor mRNA in the brain of the sea lamprey (Petromyzon marinus). J Comp Neurol. 2014 Apr;522(5):1132–54. PMID: 24127055. DOI: 10.1002/cne.23481. IF: 3.225; Q2. http://www.ncbi.nlm.nih.gov/pubmed/24127055 +Pubmed+DOI
Code
PID2019-109425GB-I00. BIF
Title
Canales de potasio de doble dominio de poro (K2P-TREK) en neuronas parasimpáticas del Ganglio Intracardíaco de ratón
Funder
Ministerio de Ciencia e Innovación (MICINN)
Type
Individual
Duration
2020 – 2023
PI
José Antonio Lamas Castro
Cols.
A. Campos. L. Rueda. S. Herrera
Code
AGL2017-89648-P
Title
Un genoma para dos diseños corporales: estudios de genómica funcional y transcriptoma a nivel de genoma completo para comprender las bases genéticas de la metamorfosis en peces
Funder
Ministerio de Economía y Competitividad
Type
Individual
Duration
2018 – 2021
PI
Josep Rotllant Moragas (External PI)
Cols.
M. Megías. M. Pombal
Code
2018CONVGRUPOSSUG-FB3
Title
Potenciación de grupos de investigación. Convenio Consellería de Cultura y Universidades del SUG.
Funder
Consellería de Cultura, Educación e Ordenación Universitaria
Type
Individual
Duration
2018 – 2018
PI
José Antonio Lamas Castro
Cols.
L. Rueda. S. Herrera
Code
ED431G/02
Title
Centros Singulares: Centro de Investigación Biomédica (CINBIO)
Funder
Consellería de Cultura, Educación e Ordenación Universitaria
Type
Coordinado
Duration
2016 – 2019
PI
José Antonio Lamas Castro
Coordinator
África González Fernández (Coord. UVIGO – IIS Galicia Sur)
Cols.
L. Rueda. S. Herrera
Code
BFU2014-58999-P
Title
Caracterización de los canales de potasio de doble dominio de poro (K2P) en neuronas del ganglio nodoso y su posible papel en la sensibilidad visceral.
Funder
Ministerio de Economía y Competitividad
Type
Individual
Duration
2015 – 2018
PI
José Antonio Lamas Castro
Cols.
L. Rueda
Code
GPC2015/022
Title
Proyectos de Consolidación y estructuración de unidades de investigación competitiva del sistema universitario de Galicia 2015. Grupos con Potencial de Crecimiento (GPC)
Funder
Consellería de Cultura, Educación e Ordenación Universitaria
Type
Individual
Duration
2015 – 2017
PI
José Antonio Lamas Castro
Cols.
L. Rueda
Code
BFU2015-70067-REDC
Title
Red Temática: “La iniciativa española en canales iónicos”
Funder
Ministerio de Educación, Cultura y Deporte
Type
Coordinado
Duration
2015 – 2016
PI
José Antonio Lamas Castro
Coordinator
Antonio Ferrer Montiel (Coord. Universidad Miguel Hernández de Elche)
Cols.
L. Rueda
Code
FP7-316265-BIOCAPS
Title
Biomedical Capacities Support Program
Funder
Comisión Europea
Type
Multicéntrico
Duration
2013 – 2016
PI
José Antonio Lamas Castro
Coordinator
África González Fernández (Coord. UVIGO – IISGS)
Code
BFU2011-25371
Title
Regulación de los canales de potasio de doble dominio de poro (K2P), de la subfamilia TREK, por agonistas muscarínicos y sustancias nootropicas en neuronas del Sistema Nervioso Autónomo
Funder
Ministerio de Economía y Competitividad
Type
Individual
Duration
2012 – 2015
PI
José Antonio Lamas Castro
Code
CN 2012/273 – INB1-131H-2
Title
Contribución a un mellor coñecemento das patoloxías dende unha perspectiva multidisciplinar – Agrupación Estratégica para la Investigación en Biomedicina – INBIOMED
Funder
Consellería de Cultura, Educación e Ordenación Universitaria
Type
Coordinado
Duration
2012 – 2015
PI
José Antonio Lamas Castro
Coordinator
Ángel Rodríguez de Lera (Coord. Universidad de Vigo)
Code
CSD2008-00005
Title
The Spanish Ion Channel Initiative (SICI)
Funder
Ministerio de Economía y Competitividad
Type
Coordinado
Duration
2008 – 2014
PI
José Antonio Lamas Castro
Coordinator
Antonio Ferrer Montiel (Coord. Universidad Miguel Hernández)
Title
Canales de potasio de doble dominio de poro (K2P-TREK) en neuronas parasimpáticas del Ganglio Intracardíaco de ratón
Establishment, validation and pharmacological manipulation of long-term potentiation (early and late) in hippocampal slices from wild and transgenic mice.
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